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Comment
. 2023 Nov 6;155(11):e202313491.
doi: 10.1085/jgp.202313491. Epub 2023 Oct 17.

Rethinking replating

Ben Short
Comment

Rethinking replating

Ben Short. J Gen Physiol. .

Abstract

JGP study (In this issue, Osten et al. https://doi.org/10.1085/jgp.202313377) suggests that, by altering mechanosensitive signaling pathways, replating stem cell-derived cardiomyocytes changes myosin expression and contractile function.

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Figures

None
Felix Osten (left), Natalie Weber (center), and colleagues including Bogdan Iorga and Joachim Meissner report that replating long-term cultures of mature stem cell-derived cardiomyocytes induces temporary changes in myosin expression and contractile function. The vast majority of long-term cultured stem cell-derived cardiomyocytes (top row) exclusively express β-MyHC (red). But many replated cells (bottom row) express α-MyHC (green) as well as, or instead of, β-MyHC.
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Comment on

References

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