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. 2024 Jan 8;30(2):e202303165.
doi: 10.1002/chem.202303165. Epub 2023 Nov 2.

Catalytic Asymmetric Synthesis of N-N Biaryl Atropisomers

Jia Feng  1 , Ren-Rong Liu  1
Affiliations

Catalytic Asymmetric Synthesis of N-N Biaryl Atropisomers

Jia Feng et al. Chemistry. .

Abstract

Atropisomers have emerged as important structural scaffolds in natural products, drug design, and asymmetric synthesis. Recently, N-N biaryl atropisomers have drawn increasing interest due to their unique structure and relatively stable axes. However, its asymmetric synthesis remains scarce compared to its well-developed C-C biaryl analogs. In this concept, we summarize the asymmetric synthesis of N-N biaryl atropisomers including N-N pyrrole-pyrrole, N-N pyrrole-indole, N-N indole-indole, and N-N indole-carbazole, during which a series synthetic strategies are highlighted. Also, a synthetic evolution is briefly reviewed and an outlook of N-N biaryl atropisomers synthesis is offered.

Keywords: asymmetric synthesis; atropisomers; enantioselectivity; indoles; palladium.

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