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Review
. 2024 Mar 1;147(3):755-765.
doi: 10.1093/brain/awad360.

Glioma-associated mesenchymal stem cells

Qing-Mei Kang  1   2   3   4   5 , Jun Wang  1   3   4   5 , Shi-Man Chen  1   3   4   5 , Si-Rong Song  1   3   4   5 , Shi-Cang Yu  1   3   4   5
Affiliations
Review

Glioma-associated mesenchymal stem cells

Qing-Mei Kang et al. Brain. .

Abstract

Recent studies have revealed that glioma-associated mesenchymal stem cells play instrumental roles in tumorigenesis and tumour progression and cannot be ignored as a cellular component of the glioma microenvironment. Nevertheless, the origin of these cells and their roles are poorly understood. The only relevant studies have shown that glioma-associated mesenchymal stem cells play a large role in promoting tumour proliferation, invasion and angiogenesis. This review provides a comprehensive summary of their discovery and definition, origin, differences from other tissue-derived mesenchymal stem cells, spatial distribution, functions and prognostic and therapeutic opportunities to deepen the understanding of these cells and provide new insight into the treatment of glioma.

Keywords: central nervous system; glioma; mesenchymal stem cells; microenvironment.

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