Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jan;6(1):236-40.
doi: 10.1128/mcb.6.1.236-240.1986.

Transcriptional regulation by iron of the gene for the transferrin receptor

K Rao, J B Harford, T Rouault, A McClelland, F H Ruddle, R D Klausner

Transcriptional regulation by iron of the gene for the transferrin receptor

K Rao et al. Mol Cell Biol. 1986 Jan.

Abstract

Treatment of K562 cells with desferrioxamine, a permeable iron chelator, led to an increase in the number of transferrin receptors. Increasing intracellular iron levels by treatment of cells with either human diferric transferrin or hemin lowered the level of the transferrin receptors. By using a cDNA clone of the human transferrin receptor, we showed that the changes in the levels of the receptor by iron were accompanied by alterations in the levels of the mRNA for the receptor. The rapidity of these changes indicated that the mRNA had a very short half-life. By using an in vitro transcriptional assay with isolated nuclei, we obtained evidence that this regulation occurred at the transcriptional level.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Methods Enzymol. 1985;109:572-92 - PubMed
    1. Mol Cell Biol. 1985 Apr;5(4):595-600 - PubMed
    1. Mol Cell Biol. 1981 Mar;1(3):281-8 - PubMed
    1. J Biol Chem. 1979 Sep 25;254(18):9050-8 - PubMed
    1. J Biol Chem. 1982 Sep 10;257(17):10317-23 - PubMed