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Published Erratum
. 2023 Oct 24;120(43):e2316531120.
doi: 10.1073/pnas.2316531120. Epub 2023 Oct 18.

Correction for Kim et al., Silver electroceutical technology to treat sarcopenia

No authors listed
Published Erratum

Correction for Kim et al., Silver electroceutical technology to treat sarcopenia

No authors listed. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Schematic of the silver electroceutical to restore the aged skeletal muscle into a young-phenotypic muscle. Skeletal muscle responds differently depending on ES conditions, and identical ES conditions result in different cell fates depending on young and aged skeletal muscles.
Fig. 2.
Fig. 2.
Configuration of the HiTESS platform and simulation for electric field optimization. (A) Configuration of the high-throughput electrical stimulation screening (HiTESS) assembly. (I) Bottom holder, (II) HiTESS substrate, (III) connecting PCB, (IV) chamber with O-ring, (V) upper holder, and (VI) cover. (B) Plane view of the HiTESS substrate. The black (ES) and blue (no ES) boxes indicate the individual culture well. (C) HiTESS assembly connected with HiTESS pulse generator. The HiTESS pulse generator was controlled by custom-made control software. (D) HiTESS assembly and HiTESS pulse generator are connected through the contact between the connecting PCB and the pogo pins of the pulse generator. (E) Simulation results of E- fields based on distance, width, length, and medium height.
Fig. 6.
Fig. 6.
Validation of the silver electroceutical in aged mice. (A) Schematics of the preclinical ES experiment. (B) E-field simulation process in a mouse leg based on 3D anatomy reconstructed by CT images. (C) Simulation results of E-field distribution in a mouse leg. (D) Quantification result of E-field value in the ROI of a mouse leg. (E) Representative CSA images of Type IIA muscle fibers in young and aged mice (Green; Type IIA fiber, Magenta; Laminin). (Scale bar, 200 μm.) (F) Quantification of myofiber CSA in young versus aged mice. (G) Quantification of myofiber CSA for ES conditions in aged mice. (H and I) Isometric twitch (H) and tetanus contraction (I) force measurement of soleus muscles depending on ES conditions in young and aged mice. (J and K) Representative images (Scale bar, 50 μm.) (J) and quantification (K) of the expression of PAX7 (Green) and muscle fibers (Magenta; Laminin). (L) Result of PCA. (M and N) Volcano plot of RNA sequencing transcriptome data displaying the pattern of gene expression values for young control (M) and aged 500 Hz mice (N) relative to aged control mice. (O) Venn diagram of differentially expressed genes found in aged con/young con and aged 500 Hz/young con. (P) Gene clustering heatmap of RNA sequencing using TA muscle from mice. (Q and R) Gene ontology analysis results for young control (Q) and aged 500 Hz mice (R) relative to aged control mice. (*P < 0.05; **P < 0.01; ***P < 0.001; compared to young control, #P < 0.05; ##P < 0.01; ###P < 0.001; compared to aged control).
See this image and copyright information in PMC

Erratum for

  • Silver electroceutical technology to treat sarcopenia.
    Kim MY, Shin HY, Cho SC, Yang S, Intisar A, Woo HJ, Choi YS, You CL, Kang JS, Lee YI, Park SC, Yea K, Oh TG, Downes M, Evans RM, Kim MS. Kim MY, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2300036120. doi: 10.1073/pnas.2300036120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549292 Free PMC article.

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