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. 1986 Aug;6(8):2990-3.
doi: 10.1128/mcb.6.8.2990-2993.1986.

Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts

C K Lumpkin, J E Knepper, J S Butel, J R Smith, O M Pereira-Smith

Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts

C K Lumpkin et al. Mol Cell Biol. 1986 Aug.

Abstract

Nuclear microinjection of c-H-ras DNA induced DNA synthesis in reversibly nonproliferating quiescent human cells. The proto-oncogene and oncogene forms were equally effective inducers. In contrast, c-H-ras DNA either alone or in combination with the adenovirus E1A gene did not cause terminally nondividing senescent cells to synthesize DNA.

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