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Comparative Study
. 1986 Sep;6(9):3109-16.
doi: 10.1128/mcb.6.9.3109-3116.1986.

Characterization of an activated human ros gene

C Birchmeier, D Birnbaum, G Waitches, O Fasano, M Wigler
Comparative Study

Characterization of an activated human ros gene

C Birchmeier et al. Mol Cell Biol. 1986 Sep.

Abstract

A human oncogene, mcf3, previously detected by a combination of DNA-mediated gene transfer and a tumorigenicity assay, derives from a human homology of the avian v-ros oncogene. Both v-ros and mcf3 can encode a protein with homology to tyrosine-specific protein kinases, and both mcf3 and v-ros encode a potential transmembrane domain N terminal to the kinase domain. mcf3 probably arose during gene transfer from a normal human ros gene by the loss of a putative extracellular domain. There do not appear to be any other gross rearrangements in the structure of mcf3.

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References

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