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. 2023 Nov;25(11):1551-1553.
doi: 10.1038/s41556-023-01246-1.

A guide to studying mitochondria transfer

Snigdha Tiash  1   2 , Jonathan Robert Brestoff  3 , Clair Crewe  4   5
Affiliations

A guide to studying mitochondria transfer

Snigdha Tiash et al. Nat Cell Biol. 2023 Nov.

Abstract

Mitochondria can shuttle between adjacent cells or travel to distant organs by breaking away from the parent cell and entering circulation. Here, we briefly review the state of the mitochondria transfer field and discuss a methodological framework for studying mitochondria transfer.

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Conflict of interest statement

Competing Interests: JRB has pending and issued patents related to mitochondria transfer and obesity, has been a consultant for DeciBio and Flagship Pioneering within the past 12 months, receives royalties from Springer Nature, and is on the Scientific Advisory Board for LUCA Science, Inc.

Figures

Figure 1.
Figure 1.. Methodologies for establishing mitochondria transfer mechanisms.
(a) Common methodologies used to detect mitochondrial transfer and (b) mechanisms of mitochondria transfer and experimental suggestions for distinguishing between them. MDVs; mitochondrial derived vesicles, IP; immunoprecipitation, OMM; outer mitochondrial membrane, TNTs; tunneling nanotubes. Images were created using biorender.com.
See this image and copyright information in PMC

References

    1. Rustom A, Saffrich R, Markovic I, Walther P & Gerdes HH Nanotubular highways for intercellular organelle transport. Science 303, 1007–1010, doi:10.1126/science.1093133 (2004). - DOI - PubMed
    1. Spees JL, Olson SD, Whitney MJ & Prockop DJ Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci U S A 103, 1283–1288, doi:10.1073/pnas.0510511103 (2006). - DOI - PMC - PubMed
    1. Liu Z, Sun Y, Qi Z, Cao L & Ding S Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases. Cell Biosci 12, 66, doi:10.1186/s13578-022-00805-7 (2022). - DOI - PMC - PubMed
    1. Crewe C et al. Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes. Cell Metab 33, 1853–1868 e1811, doi:10.1016/j.cmet.2021.08.002 (2021). - DOI - PMC - PubMed
    1. Soubannier V et al. A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr Biol 22, 135–141, doi:10.1016/j.cub.2011.11.057 (2012). - DOI - PubMed

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