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. 2023 Oct 18;24(1):391.
doi: 10.1186/s12859-023-05504-9.

Asterics: a simple tool for the ExploRation and Integration of omiCS data

Élise Maigné #  1 , Céline Noirot #  1   2 , Julien Henry  1   3 , Yaa Adu Kesewaah  1   3 , Ludovic Badin  4 , Sébastien Déjean  3   5 , Camille Guilmineau  1   3 , Arielle Krebs  1   2 , Fanny Mathevet  1   3 , Audrey Segalini  4 , Laurent Thomassin  4 , David Colongo  4 , Christine Gaspin  1   2 , Laurence Liaubet  6 , Nathalie Vialaneix  7   8
Affiliations

Asterics: a simple tool for the ExploRation and Integration of omiCS data

Élise Maigné et al. BMC Bioinformatics. .

Abstract

Background: The rapid development of omics acquisition techniques has induced the production of a large volume of heterogeneous and multi-level omics datasets, which require specific and sometimes complex analyses to obtain relevant biological information. Here, we present ASTERICS (version 2.5), a publicly available web interface for the analyses of omics datasets.

Results: ASTERICS is designed to make both standard and complex exploratory and integration analysis workflows easily available to biologists and to provide high quality interactive plots. Special care has been taken to provide a comprehensive documentation of the implemented analyses and to guide users toward sound analysis choices regarding some specific omics data. Data and analyses are organized in a comprehensive graphical workflow within ASTERICS workspace to facilitate the understanding of successive data editions and analyses leading to a given result.

Conclusion: ASTERICS provides an easy to use platform for omics data exploration and integration. The modular organization of its open source code makes it easy to incorporate new workflows and analyses by external contributors. ASTERICS is available at https://asterics.miat.inrae.fr and can also be deployed using provided docker images.

Keywords: Data integration; Omics; Statistical analyses; Web user interface.

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Conflict of interest statement

LB, AS, LT, and DC are all employees of the company Hyphen-Stat. The other authors have no conflict of interest.

Figures

Fig. 1
Fig. 1
Overview of ASTERICS web interface. The figure illustrates the different features of ASTERICS, including data upload and edition, analyses with interactive plots, comprehensive display of the workspace, exportation of data, plots and reports, and help pages providing advice for choice of analyses and options and tips for interpretation
Fig. 2
Fig. 2
Workflow from the My workspace menu, as obtained after the importation of the four CSV files and the change of a variable type in the last dataset “Metadata” (that contains the uploaded data describing the design of the experiment)
Fig. 3
Fig. 3
Individual (top) and variable (bottom) plots obtained from the MFA of the three metabolomics datasets. The right individual plot is interactively obtained from the left one by clicking on the mixed genotype icons of the legend to remove the corresponding data from the plot and increase readability
Fig. 4
Fig. 4
Concentration of valine in plasma (left) and amniotic fluid (right) at the two ages of gestation
See this image and copyright information in PMC

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