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Review
. 2023 Oct 13:16:4503-4526.
doi: 10.2147/JIR.S418222. eCollection 2023.

Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review

Kaiyang Wang #  1 , Huhai Zhang #  2 , Lie Yuan  3   4 , Xiaoli Li  3   4 , Yongqing Cai  1
Affiliations
Review

Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review

Kaiyang Wang et al. J Inflamm Res. .

Abstract

Hyperoside is a flavonol glycoside mainly found in plants of the genera Hypericum and Crataegus, and also detected in many plant species such as Abelmoschus manihot, Ribes nigrum, Rosa rugosa, Agrostis stolonifera, Apocynum venetum and Nelumbo nucifera. This compound exhibits a multitude of biological functions including anti-inflammatory, antidepressant, antioxidative, vascular protective effects and neuroprotective effects, etc. This review summarizes the quantification, original plant, chemical structure and property, structure-activity relationship, pharmacologic effect, pharmacokinetics, toxicity and clinical application of hyperoside, which will be significant for the exploitation for new drug and full utilization of this compound.

Keywords: chemical structure; hyperoside; original plant; pharmacokinetics; pharmacology; toxicity.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The outline of review.
Figure 2
Figure 2
Structure and structure–activity of hyperoside. Chemical structural formula of hyperoside (a), Spatial structure diagram of hyperoside (b).
Figure 3
Figure 3
The possible molecular mechanisms of hyperoside in anti-oxidant effect, anti-inflammatory effect, cardiovascular protective effects, anti-depressant effect, neuroprotective effect and hepatoprotective effect.
Figure 4
Figure 4
The possible molecular mechanisms of hyperoside in anti-cancer (breast, lung, pancreatic, skin, thyroid, renal, colon, liver, prostate and uterine).
See this image and copyright information in PMC

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