Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep 28:42:100612.
doi: 10.1016/j.mmcr.2023.100612. eCollection 2023 Dec.

Peritoneal dialysis-associated peritonitis from pauci-septated mold: Life-threatening but curable

Theerachai Thammathiwat  1 , Sajja Tatiyanupanwong  2 , Uraiwan Parinyasiri  3 , Dhammika Leshan Wannigama  4   5 , Tanittha Chatsuwan  4   5 , Talerngsak Kanjanabuch  6   7
Affiliations

Peritoneal dialysis-associated peritonitis from pauci-septated mold: Life-threatening but curable

Theerachai Thammathiwat et al. Med Mycol Case Rep. .

Abstract

Two cases of PD-associated peritonitis due to Cunninghamella (C. bertholletiae and C. guizhouensis) were reported here with favorable outcomes, albeit presenting with septicemia. Both patients presented with classic features of bacterial peritonitis, cloudy effluent with a neutrophil predominance, followed by fever and septicemia/septic shock. The pathogen species were confirmed and verified by molecular phylogeny using universal and specific fungal primers. All isolations were susceptible/intermediately susceptible to amphotericin B but resistant to other antifungal agents, including triazoles, caspofungin, and terbinafine. Both cases were successfully treated with timely PD catheter removal and antifungal medications for 2-4 weeks.

Keywords: Cunninghamella-associated peritonitis; Fungal peritonitis; Mucormycosis; Peritoneal dialysis.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Wet smear mounted with potassium hydroxide (KOH) demonstrates branching pauci-septate filamentous mold 400x [A] and 1,000x [E] Fungal colonies of Cunninghamella bertholletiae and C. guizhouensis on Sabouraud Dextrose Agar (SDA) agar plates at day 2 (B, F) and day 6 (C, G), respectively. Sporangiola on branched sporangiophores of Cunninghamella bertholletiae and C. guizhouensis (lactophenol cotton blue staining, LPCB x400) [D, H], respectively.
See this image and copyright information in PMC

References

    1. Li P.K., Chow K.M., Cho Y., Fan S., Figueiredo A.E., Harris T., et al. ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment. Perit. Dial. Int. 2022;42:110–153. - PubMed
    1. Kanjanabuch T., Nopsopon T., Chatsuwan T., Purisinsith S., Johnson D.W., Udomsantisuk N., et al. Predictors and outcomes of peritoneal dialysis-related infections due to filamentous molds (MycoPDICS) PLoS One. 2022;17 - PMC - PubMed
    1. Chamroensakchai T., Sanaklang N., Hurdeal V.G., Banjongjit A., Hyde K.D., Kanjanabuch T. Candida nivariensis, an emerging fungus causing peritonitis in a patient receiving peritoneal dialysis. Med. Mycol. Case Rep. 2023;39:5–7. - PMC - PubMed
    1. Sookto P., Kanjanabuch T., Chamroensakchai T., Thongbor N., Eiam-Ong S. Peritonitis after exposure to biocontrol-agent fumes containing Talaromyces flavus: a case report in peritoneal dialysis patient. BMC Nephrol. 2022;23:279. - PMC - PubMed
    1. Parinyasiri U., Uppamai S., Chamroensakchai T., Sirinual S., Sukmee K., Banjongjit A., et al. Peritonitis due to Aspergillus tamarii in peritoneal dialysis patients. Med. Mycol. Case Rep. 2023;40:44–46. - PMC - PubMed

LinkOut - more resources