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. 2023 Oct 18;16(10):1712-1717.
doi: 10.18240/ijo.2023.10.22. eCollection 2023.

Axial length shortening in myopic children with Stickler syndrome after repeated low-level red-light therapy

Xiang-Hua Tang  1 , Meng-Ting Yu  1 , Yin Hu  1 , Ming-Guang He  1   2   3 , Xiao Yang  1
Affiliations

Axial length shortening in myopic children with Stickler syndrome after repeated low-level red-light therapy

Xiang-Hua Tang et al. Int J Ophthalmol. .

Abstract

Aim: To report the myopia-controlling effect of repeated low-level red-light (RLRL) therapy in patients with Stickler syndrome (STL), an inherited collagenic disease typically presenting with early onset myopia.

Methods: Three STL children, aged 3, 7, and 11y, received RLRL therapy throughout the follow-up period of 17, 3, and 6mo, respectively after exclusion of fundus anomalies. Data on best-corrected visual acuity (BCVA), intraocular pressure, cycloplegic subjective refraction, ocular biometrics, scanning laser ophthalmoscope, optical coherence tomography, genetic testing, systemic disease history, and family history were recorded.

Results: At the initiation of the RLRL therapy, the spherical equivalent (SE) of 6 eyes from 3 patients ranged from -3.75 to -20.38 D, axial length (AL) were from 23.88 to 30.68 mm, and BCVA were from 0.4 to 1.0 (decimal notation). Myopia progression of all six eyes slowed down after RLRL therapy. AL in five out of the six eyes shortened -0.07 to -0.63 mm. No side effects were observed.

Conclusion: Three cases of STL whose progression of myopic shift and AL elongation are successfully reduced and even reversed after RLRL therapy.

Keywords: Stickler syndrome; axial length shortening; myopia; repeated low-level red-light therapy.

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Figures

Figure 1
Figure 1. Time course of cycloplegic spherical equivalent refraction and ocular AL
Cycloplegic SE refraction of 3 STL patients (Cases 1–3) were shown in A–C, and AL were shown in D–F, respectively. The dotted line showed the time when patients began repeated low-level red-light therapy. STL: Stickler syndrome; SE: Spherical equivalent; AL: Axial length.
See this image and copyright information in PMC

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