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. 2023 Apr-Jun;27(2):323-327.
doi: 10.4103/jomfp.jomfp_2_23. Epub 2023 Jul 13.

Expression of CD 20 B-Lymphocyte in oral epithelial dysplasia and oral squamous cell carcinoma: A comparative immunohistochemistry study

Anela Thomas  1 , T Smitha  1 , Kavita Rao  1 , N S Priya  1 , H S Sheethal  1 , S Chitra  1
Affiliations

Expression of CD 20 B-Lymphocyte in oral epithelial dysplasia and oral squamous cell carcinoma: A comparative immunohistochemistry study

Anela Thomas et al. J Oral Maxillofac Pathol. 2023 Apr-Jun.

Abstract

Background: As the progressive trends in the field of immunotherapy, it is very favourable to reconsider the role played by B lymphocytes in the tumor microenvironment. Both the protumorogenic and antitumorogenic responses have to be evaluated to formulate an effective immunotherapeutic protocol.

Aim and objective: The study was primarily conducted to assess the qualitative expression of B lymphocytes in pretumorogenic (oral epithelial dysplasia) and tumorogenic environment (oral squamous cell carcinoma). The differential immunohistochemical staining of CD 20 immune marker was assessed in about 60 cases that included 30 cases of oral epithelial dysplasia and 30 cases of oral squamous cell carcinoma.

Results: The study found significant correlation between CD 20 IHC immune expression and histopathological diagnosis along with significant correlation between the subject's age group and histopathological diagnosis.

Conclusion: Modulating the immune response in a precancerous state can be highly beneficial in implementing better immunotherapeutic strategies to treat or prevent malignancy at an early stage.

Keywords: CD 20 (cluster differentiate 20); IHC (immunohistochemistry); OED (oral epithelial dysplasia); OSCC (oral squamous cell carcinoma).

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Conflict of interest statement

There are no conflicts of interest.

References

    1. Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020;6:92. - PMC - PubMed
    1. Ribatti D. The concept of immune surveillance against tumors. The first theories. Oncotarget. 2017;8:7175–80. - PMC - PubMed
    1. Cancer Genome Atlas N. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015;517:576–82. - PMC - PubMed
    1. Downs-Canner SM, Meier J, Vincent BG, Serody JS. B Cell function in the tumor microenvironment. Annu Rev Immunol. 2022;40:169–93. - PubMed
    1. Abdulla R, Adyanthaya S, Kini P, Mohanty V, D'Souza N, Subbannayya Y. Clinicopathological analysis of oral squamous cell carcinoma among the younger age group in coastal Karnataka, India: A retrospective study. J Oral Maxillofac Pathol. 2018;22:180–7. - PMC - PubMed