Force opens a monomeric channel pore

Wenjun Guo¹, Lei Chen²

Affiliations

¹ State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China.
² State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; National Biomedical Imaging Center, Peking University, Beijing, 100871, China. Electronic address: chenlei2016@pku.edu.cn.

PMID: 37857087
DOI: 10.1016/j.neuron.2023.08.029

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Force opens a monomeric channel pore

Wenjun Guo et al. Neuron. 2023.

Free article

. 2023 Oct 18;111(20):3135-3137.

doi: 10.1016/j.neuron.2023.08.029.

Authors

Wenjun Guo¹, Lei Chen²

Affiliations

¹ State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China.
² State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; National Biomedical Imaging Center, Peking University, Beijing, 100871, China. Electronic address: chenlei2016@pku.edu.cn.

PMID: 37857087
DOI: 10.1016/j.neuron.2023.08.029

Abstract

In this issue of Neuron, Zheng et al.¹ report the monomeric architecture of mechanosensitive ion channels TMEM63A and TMEM63B. They show that these high-threshold channels function as monomers on the plasma membrane.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels.
Zheng W, Rawson S, Shen Z, Tamilselvan E, Smith HE, Halford J, Shen C, Murthy SE, Ulbrich MH, Sotomayor M, Fu TM, Holt JR. Zheng W, et al. Neuron. 2023 Oct 18;111(20):3195-3210.e7. doi: 10.1016/j.neuron.2023.07.006. Epub 2023 Aug 4. Neuron. 2023. PMID: 37543036 Free PMC article.

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Force opens a monomeric channel pore

Affiliations

Force opens a monomeric channel pore

Authors

Affiliations

Abstract

Conflict of interest statement

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