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Comment
. 2023 Oct 20;8(1):389.
doi: 10.1038/s41392-023-01643-w.

B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy

Xinyu Tian  1   2 , Xiangyun Zheng  1   2 , Dong Tian  3   4
Affiliations
Comment

B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy

Xinyu Tian et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
TIM-1 blockade in B cells enhances the sensing of IFN by B cells. This leads to an augmented IFN-I response, increased B cell activation, enhanced antigen presentation, and improved co-stimulation. Consequently, there is an increase in inflammatory cytokine production and responsiveness, resulting in enhanced effector T cell responses. Created with BioRender.com
See this image and copyright information in PMC

Comment on

  • B-cell-specific checkpoint molecules that regulate anti-tumour immunity.
    Bod L, Kye YC, Shi J, Torlai Triglia E, Schnell A, Fessler J, Ostrowski SM, Von-Franque MY, Kuchroo JR, Barilla RM, Zaghouani S, Christian E, Delorey TM, Mohib K, Xiao S, Slingerland N, Giuliano CJ, Ashenberg O, Li Z, Rothstein DM, Fisher DE, Rozenblatt-Rosen O, Sharpe AH, Quintana FJ, Apetoh L, Regev A, Kuchroo VK. Bod L, et al. Nature. 2023 Jul;619(7969):348-356. doi: 10.1038/s41586-023-06231-0. Epub 2023 Jun 21. Nature. 2023. PMID: 37344597 Free PMC article.

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