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Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-23-726/coif). The authors have no conflicts of interest to declare.
Yap TA, Bardia A, Dvorkin M, Galsky MD, Beck JT, Wise DR, Karyakin O, Rubovszky G, Kislov N, Rohrberg K, Joy AA, Telli ML, Schram AM, Conte U, Chappey C, Stewart R, Stypinski D, Michelon E, Cesari R, Konstantinopoulos PA.Yap TA, et al.JAMA Oncol. 2023 Jan 1;9(1):40-50. doi: 10.1001/jamaoncol.2022.5228.JAMA Oncol. 2023.PMID: 36394849Free PMC article.
References
Yap TA, Bardia A, Dvorkin M, et al. Avelumab plus talazoparib in patients with advanced solid tumors: the JAVELIN PARP medley nonrandomized controlled trial. JAMA Oncol 2023;9:40-50. 10.1001/jamaoncol.2022.5228
-
DOI
-
PMC
-
PubMed
Huang R, Zhou PK. DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy. Signal Transduct Target Ther 2021;6:254. 10.1038/s41392-021-00648-7
-
DOI
-
PMC
-
PubMed
Cai Z, Liu C, Chang C, et al. Comparative safety and tolerability of approved PARP inhibitors in cancer: A systematic review and network meta-analysis. Pharmacol Res 2021;172:105808. 10.1016/j.phrs.2021.105808
-
DOI
-
PubMed
Cong K, Peng M, Kousholt AN, et al. Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency. Mol Cell 2021;81:3128-3144.e7. 10.1016/j.molcel.2021.06.011
-
DOI
-
PMC
-
PubMed
Li H, Liu ZY, Wu N, et al. PARP inhibitor resistance: the underlying mechanisms and clinical implications. Mol Cancer 2020;19:107. 10.1186/s12943-020-01227-0
-
DOI
-
PMC
-
PubMed