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. 2023 Oct 4:17:1234168.
doi: 10.3389/fnhum.2023.1234168. eCollection 2023.

Identifying biomarkers for tDCS treatment response in Alzheimer's disease patients: a machine learning approach using resting-state EEG classification

Suellen Marinho Andrade  1 , Leandro da Silva-Sauer  1 , Carolina Dias de Carvalho  1 , Elidianne Layanne Medeiros de Araújo  1 , Eloise de Oliveira Lima  1 , Fernanda Maria Lima Fernandes  2 , Karen Lúcia de Araújo Freitas Moreira  3 , Maria Eduarda Camilo  3 , Lisieux Marie Marinho Dos Santos Andrade  4 , Daniel Tezoni Borges  5 , Edson Meneses da Silva Filho  5 , Ana Raquel Lindquist  5 , Rodrigo Pegado  5 , Edgard Morya  6 , Seidi Yonamine Yamauti  6 , Nelson Torro Alves  7 , Bernardino Fernández-Calvo  7   8   9 , José Maurício Ramos de Souza Neto  2
Affiliations

Identifying biomarkers for tDCS treatment response in Alzheimer's disease patients: a machine learning approach using resting-state EEG classification

Suellen Marinho Andrade et al. Front Hum Neurosci. .

Abstract

Background: Transcranial direct current stimulation (tDCS) is a promising treatment for Alzheimer's Disease (AD). However, identifying objective biomarkers that can predict brain stimulation efficacy, remains a challenge. The primary aim of this investigation is to delineate the cerebral regions implicated in AD, taking into account the existing lacuna in comprehension of these regions. In pursuit of this objective, we have employed a supervised machine learning algorithm to prognosticate the neurophysiological outcomes resultant from the confluence of tDCS therapy plus cognitive intervention within both the cohort of responders and non-responders to antecedent tDCS treatment, stratified on the basis of antecedent cognitive outcomes.

Methods: The data were obtained through an interventional trial. The study recorded high-resolution electroencephalography (EEG) in 70 AD patients and analyzed spectral power density during a 6 min resting period with eyes open focusing on a fixed point. The cognitive response was assessed using the AD Assessment Scale-Cognitive Subscale. The training process was carried out through a Random Forest classifier, and the dataset was partitioned into K equally-partitioned subsamples. The model was iterated k times using K-1 subsamples as the training bench and the remaining subsample as validation data for testing the model.

Results: A clinical discriminating EEG biomarkers (features) was found. The ML model identified four brain regions that best predict the response to tDCS associated with cognitive intervention in AD patients. These regions included the channels: FC1, F8, CP5, Oz, and F7.

Conclusion: These findings suggest that resting-state EEG features can provide valuable information on the likelihood of cognitive response to tDCS plus cognitive intervention in AD patients. The identified brain regions may serve as potential biomarkers for predicting treatment response and maybe guide a patient-centered strategy.

Clinical trial registration: https://classic.clinicaltrials.gov/ct2/show/NCT02772185?term=NCT02772185&draw=2&rank=1, identifier ID: NCT02772185.

Keywords: Alzheimer’s disease; artificial intelligence; electroencephalography; machine learning; transcranial direct current stimulation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Random Forest working diagram representation.
Figure 2
Figure 2
The mathematical representation of Random Forest's final classification prediction.
Figure 3
Figure 3
The Random Forest prediction equation.
Figure 4
Figure 4
The average classification error for the best channel combinations per brains regions. (A) Montage of transcranial direct current stimulation (tDCS) sessions according to the EEG 10/20 System. (B) Classification accuracy of individual channels based on cognition labels. White dots indicate the channels with highest accuracy.
See this image and copyright information in PMC

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