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. 2023 May;3(1):77-86.
doi: 10.1016/j.yao.2023.01.017. Epub 2023 Apr 7.

Advances in Blood-Brain Barrier Disruption to Facilitate Drug Delivery for Infiltrative Gliomas

Andrew Gould  1   2 , Victor Andrés Arrieta Gonzales  1   2 , Crismita Clement Dmello  1   2 , Ruth Saganty  1   3 , Rimas V Lukas  2   4 , Daniel Y Zhang  1   3 , Amy B Heimberger  1   2 , Michael Canney  5 , Alexandre Carpentier  6   7 , Carole Desseaux  5 , Guillaume Bouchoux  5 , Roger Stupp  1   2   4 , Adam M Sonabend  1   2
Affiliations

Advances in Blood-Brain Barrier Disruption to Facilitate Drug Delivery for Infiltrative Gliomas

Andrew Gould et al. Adv Oncol. 2023 May.
No abstract available

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Figures

Figure 1:
Figure 1:. LIPU/MB - Mediated Opening of the Blood-Brain Barrier
A) Cartoon illustration of human patient undergoing focused ultrasound BBB opening. Extracranial ultrasound emitters are targeted towards a region of brain and emit low intensity ultrasound waves. Lower panel shows the same patient, with an implantable ultrasound device positioned over the target tissue B) MRI imaging is often used to confirm BBB opening. The extravasation of contrast enhancement agent on a post-treatment MRI is often taken as an indicator of effective BBB opening. C) Illustration of LIPU/MB-mediated BBB opening at the level of the cerebral vasculature. The mechanical force exerted on the endothelium by the oscillating microbubbles alters the confirmation of tight junctions, allowing for paracellular diffusion of circulating drugs into the parenchyma. Caveolar transcytosis can also be a mechanism of enhanced drug delivery following FUS.
See this image and copyright information in PMC

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