Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct 11;6(4):e000599.
doi: 10.1136/wjps-2023-000599. eCollection 2023.

Predictors of surgical complications in boys with hypospadias: data from an internationa registry

Kathryn Scougall  1 , Jillian Bryce  1 , Federico Baronio  2 , Rachel L Boal  3 , Jose Roberto Castera  4 , Sebastián Castro  4 , Tim Cheetham  3 , Eduardo Corrêa Costa  5 , Feyza Darendeliler  6 , Justin H Davies  7 , Mirjam Dirlewanger  8 , Gabriella Gazdagh  7 , Evgenia Globa  9 , Gil Guerra-Junior  10 , Tulay Guran  11 , Gloria Herrmann  12 , Paul-Martin Holterhus  13 , Ahsen Karagözlü Akgül  14 , Renata Markosyan  15 , Kenneth McElreavey  16 , Marcio Lopes Miranda  10 , Anna Nordenstrom  17 , Stuart O'Toole  18 , Sukran Poyrazoglu  6 , Gianni Russo  19 , Valerie Schwitzgebel  8 , Marianna Stancampiano  19 , Michael Steigert  20 , S Faisal Ahmed  1 , Angela K Lucas-Herald  1
Affiliations

Predictors of surgical complications in boys with hypospadias: data from an internationa registry

Kathryn Scougall et al. World J Pediatr Surg. .

Abstract

Background: Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence.

Methods: Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher's exact tests and spearman's correlation tests were performed on the data to assess associations between clinical factors and complication rates.

Results: Of the 551 eligible boys, data were available on 160 (29%). Within the cohort, the median (range) External Masculinization Score (EMS) was 6 (2, 9). All presented with one or more additional genital malformation and 61 (38%) presented with additional extragenital malformations. Disorders of androgen action, androgen synthesis and gonadal development were diagnosed in 28 (18%), 22 (14%) and 9 (6%) boys, respectively. The remaining 101 (62%) patients were diagnosed as having non-specific 46,XY Disorders of Sex Development. Eighty (50%) boys had evidence of abnormal biochemistry, and gene variants were identified in 42 (26%). Median age at first hypospadias surgery was 2 years (0, 9), and median length of follow-up was 5 years (0, 17). Postsurgical complications were noted in 102 (64%) boys. There were no significant associations with postsurgical complications.

Conclusions: Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications. No clinical factors were significantly associated with complication rates. High complication rates with no observable cause suggest the involvement of other factors which need investigation.

Keywords: Endocrinology; Pediatrics.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Consort diagram of included data.
Figure 2
Figure 2
Frequency of complication according to additional extragenital malformation. CHD, congenital heart defect; CNS, central nervous system; ENT, ear nose and throat; GI, gastrointestinal; MS, musculoskeletal; SGA, small for gestational age.
See this image and copyright information in PMC

References

    1. Ahmed SF, Dobbie R, Finlayson AR, et al. Prevalence of hypospadias and other genital anomalies among singleton births, 1988-1997, in Scotland. Arch Dis Child Fetal Neonatal Ed 2004;89:F149–51. 10.1136/adc.2002.024034 - DOI - PMC - PubMed
    1. Long CJ, Chu DI, Tenney RW, et al. Intermediate-term followup of proximal hypospadias repair reveals high complication rate. J Urol 2017;197:852–8. 10.1016/j.juro.2016.11.054 - DOI - PMC - PubMed
    1. Wu Y, Wang J, Zhao T, et al. Complications following primary repair of non-proximal hypospadias in children: a systematic review and meta-analysis. Front Pediatr 2020;8:579364. 10.3389/fped.2020.579364 - DOI - PMC - PubMed
    1. van der Horst HJR, de Wall LL. Erratum to: hypospadias, all there is to know. Eur J Pediatr 2017;176:1443. 10.1007/s00431-017-2971-3 - DOI - PMC - PubMed
    1. Keays MA, Dave S. Current hypospadias management: diagnosis, surgical management, and long-term patient-centred outcomes. Can Urol Assoc J 2017;11:S48–53. 10.5489/cuaj.4386 - DOI - PMC - PubMed

LinkOut - more resources