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Review
. 2023 Aug 9;32(14):1993-2011.
doi: 10.1007/s10068-023-01381-3. eCollection 2023 Dec.

Non-digestible oligosaccharides-based prebiotics to ameliorate obesity: Overview of experimental evidence and future perspectives

G Divyashri  1 , Pothiyappan Karthik  2 , T P Krishna Murthy  1 , Dey Priyadarshini  1 , Kakarla Raghava Reddy  3 , Anjanapura V Raghu  4 , Vinoth Kumar Vaidyanathan  5
Affiliations
Review

Non-digestible oligosaccharides-based prebiotics to ameliorate obesity: Overview of experimental evidence and future perspectives

G Divyashri et al. Food Sci Biotechnol. .

Abstract

The diverse populations reportedly suffer from obesity on a global scale, and inconclusive evidence has indicated that both environmental and genetic factors are associated with obesity development. Therefore, a need exists to examine potential therapeutic or prophylactic molecules for obesity treatment. Prebiotics with non-digestible oligosaccharides (NDOs) have the potential to treat obesity. A limited number of prebiotic NDOs have demonstrated their ability as a convincing therapeutic solution to encounter obesity through various mechanisms, viz., stimulating beneficial microorganisms, reducing the population of pathogenic microorganisms, and also improving lipid metabolism and glucose homeostasis. NDOs include pectic-oligosaccharides, fructo-oligosaccharides, xylo-oligosaccharides, isomalto-oligosaccharides, manno-oligosaccharides and other oligosaccharides which significantly influence the overall human health by different mechanisms. This review provides the treatment of obesity benefits by incorporating these prebiotic NDOs, according to established scientific research, which shows their good effects extend beyond the colon.

Keywords: Beneficial microorganisms; Lipid metabolism and Glucose homeostasis; Non-digestible oligosaccharides; Obesity; Prebiotics.

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Conflict of interest statement

Conflict of interestThe authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Relationship between intestinal microbiota, prebiotics and obesity
Fig. 2
Fig. 2
Mechanism of prebiotic NDOs converted into probiotics towards the application of neural, metabolic, hormonal and inflammatory systems
See this image and copyright information in PMC

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