Antigens localized to B-cell follicles are protected from proteases: Implications for allergy and allergen immunotherapy

Danielle Della Libera^{1

2

3}, Sara Fortier^{1

2

3}, Joshua F E Koenig^{1

2

3}

Affiliations

¹ Division of Clinical Immunology and Allergy, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
² McMaster Immunology Research Centre, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
³ Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, McMaster University, Ontario, Hamilton, Canada.

Danielle Della Libera et al. Allergy. 2024 Feb.

. 2024 Feb;79(2):537-539.

doi: 10.1111/all.15928. Epub 2023 Oct 20.

Danielle Della Libera^{1

2

3}, Sara Fortier^{1

2

3}, Joshua F E Koenig^{1

2

3}

¹ Division of Clinical Immunology and Allergy, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
² McMaster Immunology Research Centre, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
³ Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, McMaster University, Ontario, Hamilton, Canada.

No abstract available

References

1. Victora GD, Nussenzweig MC. Germinal centers. Annu Rev Immunol. 2022;40(1):413-442.
1. Smith BA, Gartner S, Liu Y, et al. Persistence of infectious HIV on follicular dendritic cells. J Immunol. 2001;166(1):690-696.
1. Aung A, Cui A, Maiorino L, et al. Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science. 2023;379(6630):eabn8934.
1. Martínez-Riaño A, Wang S, Boeing S, et al. Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network. Nat Immunol. 2023;24:1-14.
1. Jiménez-Saiz R, Chu DK, Mandur TS, et al. Lifelong memory responses perpetuate humoral TH2 immunity and anaphylaxis in food allergy. J Allergy Clin Immunol. 2017;140(6):1604-1615.e5.