Genetic modifiers of repeat expansion disorders
- PMID: 37861103
- PMCID: PMC10754329
- DOI: 10.1042/ETLS20230015
Genetic modifiers of repeat expansion disorders
Abstract
Repeat expansion disorders (REDs) are monogenic diseases caused by a sequence of repetitive DNA expanding above a pathogenic threshold. A common feature of the REDs is a strong genotype-phenotype correlation in which a major determinant of age at onset (AAO) and disease progression is the length of the inherited repeat tract. Over a disease-gene carrier's life, the length of the repeat can expand in somatic cells, through the process of somatic expansion which is hypothesised to drive disease progression. Despite being monogenic, individual REDs are phenotypically variable, and exploring what genetic modifying factors drive this phenotypic variability has illuminated key pathogenic mechanisms that are common to this group of diseases. Disease phenotypes are affected by the cognate gene in which the expansion is found, the location of the repeat sequence in coding or non-coding regions and by the presence of repeat sequence interruptions. Human genetic data, mouse models and in vitro models have implicated the disease-modifying effect of DNA repair pathways via the mechanisms of somatic mutation of the repeat tract. As such, developing an understanding of these pathways in the context of expanded repeats could lead to future disease-modifying therapies for REDs.
Keywords: DNA synthesis and repair; cag repeat; genetic modifier; repeat expansion; somatic DNA expansion; somatic instability.
© 2023 The Author(s).
Conflict of interest statement
The authors declare that there are no competing interests associated with the manuscript.
Figures

Similar articles
-
Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.Hum Mol Genet. 2020 Nov 4;29(18):3044-3053. doi: 10.1093/hmg/ddaa196. Hum Mol Genet. 2020. PMID: 32876667 Free PMC article.
-
Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington's Disease.J Huntingtons Dis. 2021;10(1):149-163. doi: 10.3233/JHD-200423. J Huntingtons Dis. 2021. PMID: 33579860 Free PMC article. Review.
-
MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice.PLoS Genet. 2013;9(2):e1003280. doi: 10.1371/journal.pgen.1003280. Epub 2013 Feb 28. PLoS Genet. 2013. PMID: 23468640 Free PMC article.
-
Inherited CAG.CTG allele length is a major modifier of somatic mutation length variability in Huntington disease.DNA Repair (Amst). 2007 Jun 1;6(6):789-96. doi: 10.1016/j.dnarep.2007.01.002. Epub 2007 Feb 12. DNA Repair (Amst). 2007. PMID: 17293170
-
Disease-associated repeat instability and mismatch repair.DNA Repair (Amst). 2016 Feb;38:117-126. doi: 10.1016/j.dnarep.2015.11.008. Epub 2015 Dec 12. DNA Repair (Amst). 2016. PMID: 26774442 Review.
Cited by
-
Tissue-Specific Effects of the DNA Helicase FANCJ/BRIP1/BACH1 on Repeat Expansion in a Mouse Model of the Fragile X-Related Disorders.Int J Mol Sci. 2025 Mar 15;26(6):2655. doi: 10.3390/ijms26062655. Int J Mol Sci. 2025. PMID: 40141297 Free PMC article.
-
Structural and Dynamical Properties of Nucleic Acid Hairpins Implicated in Trinucleotide Repeat Expansion Diseases.Biomolecules. 2024 Oct 10;14(10):1278. doi: 10.3390/biom14101278. Biomolecules. 2024. PMID: 39456210 Free PMC article. Review.
-
STRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci.Genome Med. 2025 Mar 26;17(1):29. doi: 10.1186/s13073-025-01454-4. Genome Med. 2025. PMID: 40140942 Free PMC article.
-
Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington's disease decades before clinical motor diagnosis.Nat Med. 2025 Mar;31(3):807-818. doi: 10.1038/s41591-024-03424-6. Epub 2025 Jan 17. Nat Med. 2025. PMID: 39825149 Free PMC article.
-
Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens.Hum Genomics. 2024 Dec 31;18(1):141. doi: 10.1186/s40246-024-00704-7. Hum Genomics. 2024. PMID: 39736681 Free PMC article. Review.
References
-
- Scahill, R.I., Zeun, P., Osborne-Crowley, K., Johnson, E.B., Gregory, S., Parker, C.et al. (2020) Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington's disease young adult study (HD-YAS): a cross-sectional analysis. Lancet Neurol. 19, 502–512 10.1016/S1474-4422(20)30143-5 - DOI - PMC - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Research Materials