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. 2023 Oct 20;102(42):e35638.
doi: 10.1097/MD.0000000000035638.

Prevalence and risk factors associated with drug resistant bacteria in neonatal and pediatric intensive care units: A retrospective study in Saudi Arabia

Abdulrahman S Bazaid  1 , Abdu Aldarhami  2 , Nada A Bokhary  3 , Mohammed B Bazaid  3 , Mohammad F Qusty  3 , Thamer H AlGhamdi  3 , Abdullatif A Almarashi  4
Affiliations

Prevalence and risk factors associated with drug resistant bacteria in neonatal and pediatric intensive care units: A retrospective study in Saudi Arabia

Abdulrahman S Bazaid et al. Medicine (Baltimore). .

Abstract

Successful empirical antibiotic therapy for infected patients with multi drug resistant bacteria (MDR) can be challenging task in various healthcare settings, including neonatal and pediatric intensive care units (NICU and PICU, respectively), unless an up-to-date comprehensive local antibiogram data is available. Thus, this project aimed to investigate the prevalence of MDR among PICU and NICU patients as well as the identification of risk factors associated with recovered MDR bacteria. This was a retrospective study of PICU and NICU patients admitted with bacterial infection of MDR organisms between October 2020 and May 2021. Frequency distribution, Chi-square test were applied to verify the significance differences among subgroups and to identify risk factor associated with each group. About 36.4% of recruited patients were neonates, while the remaining percentage (63.6%) were pediatric. The most predominant site of infection among these patients were revealed as urinary tract (35%), followed by bloodstream (20.0%), wound/skin (12.9%) and respiratory system (11.4%). Methicillin-resistant Staphylococcus aureus (MRSA) was identified as the most common microbe across these sites of infections (30.7%), followed by Escherichia coli (25.0%), Klebsiella pneumoniae (22.9%) and Serratia (10.0%). High mortality rate was significantly associated with patients who were on mechanical ventilators (28.9%, OR 5.5; 95% CI), followed by patients had invasive operation (27.5%, OR, 8.04; 95% CI) and those who required a total parental nutrition (TPN) since almost one-half of these cases have (46.2%) died. In addition, mortality rate was relatively higher among patients infected with species of Serratia (28.6%) and Enterobacter (20.0%). These data highlighted that MRSA was the main MDR bacteria isolated from PICU and NICU followed by gram-negative bacteria, which were associated with high mortality rate. Therefore, infection control measures and continuous monitoring of emerging MDR bacteria should be applied to limit the bacterial infections in NICU and PICU patients.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Distribution of organisms based on specimens and location.
Figure 2.
Figure 2.
Outcome of the cases.
See this image and copyright information in PMC

References

    1. Bazaid AS, Barnawi H, Qanash H, et al. Bacterial coinfection and antibiotic resistance profiles among hospitalised COVID-19 patients. Microorganisms. 2022;10:495. - PMC - PubMed
    1. Menz BD, Charani E, Gordon DL, et al. Surgical antibiotic prophylaxis in an era of antibiotic resistance: common resistant bacteria and wider considerations for practice. Infect Drug Resist. 2021;14:5235–52. - PMC - PubMed
    1. Dadgostar P. Antimicrobial resistance: implications and costs. Infect Drug Resist. 2019;12:3903–10. - PMC - PubMed
    1. Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health. 2015;109:309–18. - PMC - PubMed
    1. Wang L, Du KN, Zhao YL, et al. Risk factors of nosocomial infection for infants in neonatal intensive care units: a systematic review and meta-analysis. Med Sci Monit. 2019;25:8213–20. - PMC - PubMed

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