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. 2023 Oct 20;18(10):e0291593.
doi: 10.1371/journal.pone.0291593. eCollection 2023.

Somno-Art Software identifies pathology-induced changes in sleep parameters similarly to polysomnography

Laurie Thiesse  1 , Luc Staner  2 , Patrice Bourgin  3   4 , Henri Comtet  3   4 , Gil Fuchs  1 , Debora Kirscher  1 , Thomas Roth  5 , Jean Yves Schaffhauser  1 , Jay B Saoud  6   7 , Antoine U Viola  1
Affiliations

Somno-Art Software identifies pathology-induced changes in sleep parameters similarly to polysomnography

Laurie Thiesse et al. PLoS One. .

Abstract

Polysomnographic sleep architecture parameters are commonly used to diagnose or evaluate treatment of sleep disorders. Polysomnography (PSG) having practical constraints, the development of wearable devices and algorithms to monitor and stage sleep is rising. Beside pure validation studies, it is necessary for a clinician to ensure that the conclusions drawn with a new generation wearable sleep scoring device are consistent to the ones of gold standard PSG, leading to similar interpretation and diagnosis. This paper reports on the performance of Somno-Art Software for the detection of differences in sleep parameters between patients suffering from obstructive sleep apnea (OSA), insomniac or major depressive disorder (MDD) compared to healthy subjects. On 244 subjects (n = 26 healthy, n = 28 OSA, n = 66 insomniacs, n = 124 MDD), sleep staging was obtained from PSG and Somno-Art analysis on synchronized electrocardiogram and actimetry signals. Mixed model analysis of variance was performed for each sleep parameter. Possible differences in sleep parameters were further assessed with Mann-Whitney U-test between the healthy subjects and each pathology group. All sleep parameters, except N1+N2, showed significant differences between the healthy and the pathology group. No significant differences were observed between Somno-Art Software and PSG, except a 3.6±2.2 min overestimation of REM sleep. No significant interaction 'group'*'technology' was observed, suggesting that the differences in pathologies are independent of the technology used. Overall, comparable differences between healthy subjects and pathology groups were observed when using Somno-Art Software or polysomnography. Somno-Art proposes an interesting valid tool as an aid for diagnosis and treatment follow-up in ambulatory settings.

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Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: This study was supported by PPRS SAS. JYS and JBS are shareholders of PPRS SAS. LT, GF, DK and AUV, are employees of PPRS SAS. JBS is a payed consultant of PPRS Research lnc. JYS is shareholder of V-WATCH SA. PB, HC and LS are working in hospitals that have received monetary contribution for running the healthy study 2 and the OSA study. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1. Mann-Whitney U-test for sleep parameters between healthy subjects and OSA, insomniac or MDD patients obtained from the standard polysomnography (A) and the Somno-Art Software (B).
*p<0.05; (Mean ± standard error).
See this image and copyright information in PMC

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