A comprehension of signaling pathways and drug resistance; an insight into the correlation between microRNAs and cancer

Affiliations

¹ Department of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif 21944, Saudi Arabia. Electronic address: hashemalsaab@gmail.com.
² Research Department of Biotechnology, New Uzbekistan University, Mustaqillik Avenue 54, Tashkent 100007, Uzbekistan; Department of Oncology, School of Medicine, Central Asian University, Milliy Bog Street 264, Tashkent 111221, Uzbekistan. Electronic address: author.uzb@mail.ru.
³ Cardiology Department, College of Medicine, Al-Ayen University, Dhi-Qar, Iraq.
⁴ College of Technical Engineering, the Islamic University, Najaf, Iraq; College of Technical Engineering, the Islamic University of Al Diwaniyah, Iraq; College of Technical Engineering, the Islamic University of Babylon, Iraq.
⁵ Maternal and Child Health Nursing Department, King Saud University, Riyadh, Saudi Arabia.
⁶ Medical Technical College, Al-Farahidi University, Baghdad, Iraq.
⁷ Department of Mechanical Engineering, Uttaranchal Institute of Technology, Uttaranchal University, Dehradun 248007, India.
⁸ College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna 66002, Iraq.
⁹ College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq.
¹⁰ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.

PMID: 37862919
DOI: 10.1016/j.prp.2023.154848

Review

A comprehension of signaling pathways and drug resistance; an insight into the correlation between microRNAs and cancer

Hashem O Alsaab et al. Pathol Res Pract. 2023 Nov.

. 2023 Nov:251:154848.

doi: 10.1016/j.prp.2023.154848. Epub 2023 Oct 5.

Affiliations

¹ Department of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif 21944, Saudi Arabia. Electronic address: hashemalsaab@gmail.com.
² Research Department of Biotechnology, New Uzbekistan University, Mustaqillik Avenue 54, Tashkent 100007, Uzbekistan; Department of Oncology, School of Medicine, Central Asian University, Milliy Bog Street 264, Tashkent 111221, Uzbekistan. Electronic address: author.uzb@mail.ru.
³ Cardiology Department, College of Medicine, Al-Ayen University, Dhi-Qar, Iraq.
⁴ College of Technical Engineering, the Islamic University, Najaf, Iraq; College of Technical Engineering, the Islamic University of Al Diwaniyah, Iraq; College of Technical Engineering, the Islamic University of Babylon, Iraq.
⁵ Maternal and Child Health Nursing Department, King Saud University, Riyadh, Saudi Arabia.
⁶ Medical Technical College, Al-Farahidi University, Baghdad, Iraq.
⁷ Department of Mechanical Engineering, Uttaranchal Institute of Technology, Uttaranchal University, Dehradun 248007, India.
⁸ College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna 66002, Iraq.
⁹ College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq.
¹⁰ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.

PMID: 37862919
DOI: 10.1016/j.prp.2023.154848

Abstract

Despite the development of numerous therapies, cancer remains an incurable disease due to various factors, including drug resistance produced by cancer cells. MicroRNAs (miRNAs) regulate different target genes involved in biological and pathological processes, including cancer, through post-transcriptional mechanisms. The development of drug resistance in cancer treatment is a significant barrier because it decreases drug uptake, cellular transport, and changes in proteins involved in cell proliferation, survival, and apoptotic pathways. Numerous studies have found a connection between miRNAs and the development of drug resistance in cancer cells. This paper provides a broad overview of how miRNAs regulate signaling pathways and influence treatment resistance in different cancers.

Keywords: Cancer; Chemoresistance; Drug resistance; MicroRNAs; Signaling pathways.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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A comprehension of signaling pathways and drug resistance; an insight into the correlation between microRNAs and cancer

Affiliations

A comprehension of signaling pathways and drug resistance; an insight into the correlation between microRNAs and cancer

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical