Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Oct 19;83(20):3593-3595.
doi: 10.1016/j.molcel.2023.09.030.

SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops

Natalia Gromak  1
Affiliations
Free article
Comment

SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops

Natalia Gromak. Mol Cell. .
Free article

Abstract

A recent Nature paper by Xu et al.1 describes an important link between RNA polymerase II promoter-proximal pausing and genome stability orchestrated by liquid droplet formation to reduce unwanted R-loop accumulation.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The author declares no competing interests.

Comment on

  • R-loop-dependent promoter-proximal termination ensures genome stability.
    Xu C, Li C, Chen J, Xiong Y, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H, Chen FX. Xu C, et al. Nature. 2023 Sep;621(7979):610-619. doi: 10.1038/s41586-023-06515-5. Epub 2023 Aug 9. Nature. 2023. PMID: 37557913 Free PMC article.

Publication types

Substances

LinkOut - more resources