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Comment
. 2023 Nov 13;41(11):1843-1845.
doi: 10.1016/j.ccell.2023.09.016. Epub 2023 Oct 19.

The one-two punch: TIM-3 blockade targets immune and tumor cells to knock out pediatric brain tumors

Juyeun Lee  1 , Justin D Lathia  2
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Comment

The one-two punch: TIM-3 blockade targets immune and tumor cells to knock out pediatric brain tumors

Juyeun Lee et al. Cancer Cell. .
Free article

Abstract

Diffuse midline gliomas (DMGs) pose treatment challenges due to their location within the brainstem and invasive nature. Although classical immune checkpoint inhibitors have demonstrated limited success in clinical trials, Ausejo-Mauleon et al. demonstrate TIM-3 is an effective DMG strategy, targeting both immune and tumor cells for dual therapeutic benefit.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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  • TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory.
    Ausejo-Mauleon I, Labiano S, de la Nava D, Laspidea V, Zalacain M, Marrodán L, García-Moure M, González-Huarriz M, Hervás-Corpión I, Dhandapani L, Vicent S, Collantes M, Peñuelas I, Becher OJ, Filbin MG, Jiang L, Labelle J, de Biagi-Junior CAO, Nazarian J, Laternser S, Phoenix TN, van der Lugt J, Kranendonk M, Hoogendijk R, Mueller S, De Andrea C, Anderson AC, Guruceaga E, Koschmann C, Yadav VN, Gállego Pérez-Larraya J, Patiño-García A, Pastor F, Alonso MM. Ausejo-Mauleon I, et al. Cancer Cell. 2023 Nov 13;41(11):1911-1926.e8. doi: 10.1016/j.ccell.2023.09.001. Epub 2023 Oct 5. Cancer Cell. 2023. PMID: 37802053 Free PMC article.

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