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Comment
. 2024 Mar;34(3):187-188.
doi: 10.1038/s41422-023-00885-1.

Hematopoietic memory of severe COVID-19 infection

Anaisa V Ferreira  1 , Mihai G Netea  2   3
Affiliations
Comment

Hematopoietic memory of severe COVID-19 infection

Anaisa V Ferreira et al. Cell Res. 2024 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1. Schematic diagram of COVID-19-induced hematopoietic innate immune memory.
Up to one year after severe COVID-19, HSPCs exhibit epigenetic changes, which are transmitted to their myeloid progeny. IL-6 signalling contributes to the long-term increase in myeloid function, which may play a role in the pathophysiology of long-COVID or provide some protection to secondary infections. IL-6R interleukin-6 receptor, TF transcription factor. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.
    Cheong JG, Ravishankar A, Sharma S, Parkhurst CN, Grassmann SA, Wingert CK, Laurent P, Ma S, Paddock L, Miranda IC, Karakaslar EO, Nehar-Belaid D, Thibodeau A, Bale MJ, Kartha VK, Yee JK, Mays MY, Jiang C, Daman AW, Martinez de Paz A, Ahimovic D, Ramos V, Lercher A, Nielsen E, Alvarez-Mulett S, Zheng L, Earl A, Yallowitz A, Robbins L, LaFond E, Weidman KL, Racine-Brzostek S, Yang HS, Price DR, Leyre L, Rendeiro AF, Ravichandran H, Kim J, Borczuk AC, Rice CM, Jones RB, Schenck EJ, Kaner RJ, Chadburn A, Zhao Z, Pascual V, Elemento O, Schwartz RE, Buenrostro JD, Niec RE, Barrat FJ, Lief L, Sun JC, Ucar D, Josefowicz SZ. Cheong JG, et al. Cell. 2023 Aug 31;186(18):3882-3902.e24. doi: 10.1016/j.cell.2023.07.019. Epub 2023 Aug 18. Cell. 2023. PMID: 37597510 Free PMC article.

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