Macrophages, MIFs, and MSCs: Defining an MOA in murine experimental asthma
- PMID: 37865098
- PMCID: PMC10638068
- DOI: 10.1016/j.ymthe.2023.10.010
Macrophages, MIFs, and MSCs: Defining an MOA in murine experimental asthma
Abstract
The mechanistically defined attributes of primed MSCs as here described not only provide a novel use case of MIF activated MSCs that can address the potency shortcomings of generic culture-adapted MSCs for acute lung injury but also provide some intriguing "Rosetta Stone" insights on plausible in vivo physiology of MSCs with host innate effectors such as macrophages in response to inflammation.
Copyright © 2023 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The author declares no competing interests.
Comment on
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Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma.Mol Ther. 2023 Nov 1;31(11):3243-3258. doi: 10.1016/j.ymthe.2023.09.013. Epub 2023 Sep 20. Mol Ther. 2023. PMID: 37735872 Free PMC article.
References
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- Hawthorne I.J., Dunbar H., Tunstead C., Schorpp T., Weiss D.J., Enes S.R., Dos Santos C.C., Armstrong M.E., Donnelly S.C., English K. Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma. Mol. Ther. 2023;31:3243–3258. doi: 10.1016/j.ymthe.2023.09.013. - DOI - PubMed
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