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Review
. 2024 Jan;254(Pt 1):127553.
doi: 10.1016/j.ijbiomac.2023.127553. Epub 2023 Oct 20.

Mechanisms and structure-activity relationships of polysaccharides in the intervention of Alzheimer's disease: A review

Jun Tang  1 , Muhammad Yousaf  1 , Ya-Ping Wu  1 , Qin-Qin Li  1 , Yi-Qian Xu  1 , Dong-Mei Liu  2
Affiliations
Review

Mechanisms and structure-activity relationships of polysaccharides in the intervention of Alzheimer's disease: A review

Jun Tang et al. Int J Biol Macromol. 2024 Jan.

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disease. Despite several decades of research, the development of effective treatments and responses for Alzheimer's disease remains elusive. The utilization of polysaccharides for Alzheimer's disease became more popular due to their beneficial characteristics, notably their multi-target activity and low toxicity. This review mainly focuses on the researches of recent 5 years in the regulation of AD by naturally derived polysaccharides, systematically lists the possible intervention pathways of polysaccharides from different mechanisms, and explores the structure-activity relationship between polysaccharide structural activities, so as to provide references for the intervention and treatment of AD by polysaccharides.

Keywords: Alzheimer's disease; Mechanisms; Polysaccharide; Structure-activity relationships.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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