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Review
. 2023 Dec:80:105045.
doi: 10.1016/j.msard.2023.105045. Epub 2023 Oct 11.

Anaesthetic management of people with multiple sclerosis

N Dubuisson  1 , O de Maere d'Aertrijcke  2 , M Marta  3 , S Gnanapavan  3 , B Turner  3 , D Baker  4 , K Schmierer  3 , G Giovannoni  3 , V Verma  5 , M-A Docquier  2
Affiliations
Free article
Review

Anaesthetic management of people with multiple sclerosis

N Dubuisson et al. Mult Scler Relat Disord. 2023 Dec.
Free article

Abstract

There is a lack of published guidelines on the management of patients with multiple sclerosis (MS) undergoing procedures that require anaesthesia and respective advice is largely based on retrospective studies or case reports. The aim of this paper is to provide recommendations for anaesthetists and neurologists for the management of patients with MS requiring anaesthesia. This review covers issues related to the anaesthetic management of patients with MS, with a focus on preoperative assessment, choice of anaesthetic techniques and agents, side-effects of drugs used during anaesthesia and their potential impact on the disease evolution, drug interactions that may occur, and the need to use monitoring devices. A systematic PubMed research was performed to retrieve relevant articles.

Keywords: Anaesthesia; Multiple sclerosis; Peri-operative management; Pregnancy; Preoperative assessment.

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Conflict of interest statement

Declaration of Competing Interest Oriane de Maere has no disclosure. Nicolas Dubuisson was an ECTRIMS fellow, which is unrelated to the contents of this publication. He has received travel costs from Pfizer, Merck-Serono and Genzyme unrelated to the context of this publication. Monica Marta has received honoraria and travel costs from Genzyme, AbbVie, Roche and Novartis, unrelated to the context of this publication. Sharmilee Gnanapavan has received honoraria and meeting support from Biogen, Novartis, Teva, Genzyme and research funds from Genzyme, which is unrelated to the contents of this publication. Benjamin Turner has received honoraria from Roche, Teva, Novartis, Merck-Serono, Sanofi-Genzyme and Biogen, unrelated to the context of this publication. David Baker is a founder and consultant to Canbex therapeutics and has received research funds from Canbex therapeutics, Sanofi-Genzyme and Takeda in the past 3 years. This is unrelated to the context of this publication. Klaus Schmierer has received research support from Biogen, Merck, and Novartis; speaking honoraria from, and/or served in an advisory role for, Amgen-Gensenta, Biogen, EMD Serono, Merck, Novartis, Roche, Sanofi, and Teva; and remuneration for teaching activities from AcadeMe, Medscape, and the Neurology Academy.This is unrelated to the context of this publication. Gavin Giovannoni has received fees for participation in advisory board for AbbVie Biotherapeutics, Biogen, Canbex, Ironwood, Novartis, Merck, Merck Serono, Roche, Sanofi Genzyme, Synthon, Teva and Vertex; speaker fees from AbbVie, Biogen, Bayer HealthCare,Genzyme, Merck Serono, Sanofi-Aventis and Teva. Research support from Biogen, Genzyme, Ironwood, Merck, Merck Serono and Novartis. This is unrelated to the context of this publication. Vishwajit Verma: no disclosure. Marie-Agnès Docquier: no disclosure.

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