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Review
. 2023 Dec;50(4):853-868.
doi: 10.1016/j.clp.2023.07.009. Epub 2023 Aug 31.

Anemia, Iron Supplementation, and the Brain

Tate Gisslen  1 , Raghavendra Rao  2 , Michael K Georgieff  2
Affiliations
Review

Anemia, Iron Supplementation, and the Brain

Tate Gisslen et al. Clin Perinatol. 2023 Dec.

Abstract

The developing brain is particularly vulnerable to extrinsic environmental events such as anemia and iron deficiency during periods of rapid development. Studies of infants with postnatal iron deficiency and iron deficiency anemia clearly demonstrated negative effects on short-term and long-term brain development and function. Randomized interventional trials studied erythropoiesis-stimulating agents and hemoglobin-based red blood cell transfusion thresholds to determine how they affect preterm infant neurodevelopment. Studies of red blood cell transfusion components are limited in preterm neonates. A biomarker strategy measuring brain iron status and health in the preanemic period is desirable to evaluate treatment options and brain response.

Keywords: Anemia; Biomarkers; Brain; Erythropoietin; Iron deficiency; Neurodevelopment; Premature; Transfusion.

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