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Review
. 2023 Dec;50(4):881-893.
doi: 10.1016/j.clp.2023.07.005. Epub 2023 Aug 17.

Allogenic Cord Blood Transfusion in Preterm Infants

Luciana Teofili  1 , Patrizia Papacci  2 , Carmen Giannantonio  3 , Maria Bianchi  4 , Caterina Giovanna Valentini  4 , Giovanni Vento  2
Affiliations
Review

Allogenic Cord Blood Transfusion in Preterm Infants

Luciana Teofili et al. Clin Perinatol. 2023 Dec.

Abstract

Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.

Keywords: Blood product; Cord blood; Fetal hemoglobin; Oxidative stress; Preterm neonates.

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