Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2023 Oct 20;40(6):435-444.
doi: 10.4274/balkanmedj.galenos.2023.2023-6-90.

The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye

Fethi Gül  1 , Umut Sabri Kasapoğlu  2 , Mehmet Süleyman Sabaz  3 , Pınar Ay  4 , Burçin Doruk Oktay  1 , Gülbahar Çalışkan  5 , Nalan Demir  6 , İsmet Sayan  7 , Feyyaz Kabadayı  7 , Gülsüm Altuntaş  8 , Ayça Gümüş  9 , Hülya Kırca  9 , Deniz Şanlı  10 , Fatma Acil  11 , Andaç Dedeoğlu  11 , Sedef Gülçin Ural  12 , İrem Akın Şen  12 , Eda Macit Aydın  13 , Hakan Dayanır  13 , Birgül Yelken  14 , İlkay Ceylan  15 , Osman Özcan Aydın  14 , Güneş Eskidemir  16 , Ahmet Aytekin  17 , Melike Cengiz  18 , Ülkü Arslan  18 , Devrim Akdağ  19 , Gülçin Hilal Alay  20 , Esra Tekin  21 , Volkan Yarar  22 , Kemal Tolga Saracoğlu  23 , Funda Gök  24 , Volkan Alparslan  25 , Verda Tuna  26 , Murside Yıldız  27 , Nimet Şenoğlu  28 , Cenk Kıraklı  29 , Süleyman Yıldırım  29 , Kübra Saçar Kübüç  30 , Ayşen Erer  31 , Hamza Gültekin  32 , Kezban Özmen Süner  33 , Özge Kuzgun  33 , Çağatay Erman Öztürk  34 , Aydın Karahan  35 , Okan Deveci  35 , Mustafa Ay  36 , Dilara Tüfek Öztan  36 , Seda Banu Akıncı  37 , Melahat Yalçın Solak  37 , Süha Bozbay  38 , Serhat Özçiftçi  38 , Kamil Gönderen  39 , Ahmet Oğuzhan Küçük  40 , Berna Uyan  41 , Gülseren Elay  42 , Nazlıhan Boyacı  43 , Mustafa Timurkaan  8 , Ebru Karakoç  44 , Lerzan Doğan  45 , Erdem Yalçınkaya  46 , Leyla Kazancıoğlu  47 , Gül Erdal Dönmez  48 , Barış Yılmaz  48 , Dursun Fırat Ergül  49 , Maruf Boran  49 , Hüseyin Özkarakaş  50 , Buğra Karakaş  51 , Perihan Ergin Özcan  52 , İlkay Anaklı  52 , Mustafa Kemal Bayar  53 , Didem Yüksel Yüksel  53 , Şükriye Akdağ  54 , Özcan Pişkin  55 , Sibel Temur  56 , Selin Eyüpoğlu  57 , Elvan Tekir Yılmaz  58 , Gizem Zaim Avcı  59 , Raziye Turan  59 , Fatma Alkan Bayburt  59 , Helin Şahintürk  60 , Bülent Güçyetmez  61 , Mustafa Muhlis Alparslan  62 , Metin Yarıcı  63 , Fatma Yıldırım  64 , Abdulkadir Yektaş  65 , Güçlü Yaman  66 , Oktay Demirkıran  67 , İsmail Cinel  1
Affiliations
Observational Study

The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye

Fethi Gül et al. Balkan Med J. .

Abstract

Background: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear.

Aims: To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19.

Study design: Multicenter prospective observational clinical study.

Methods: This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated.

Results: As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores (p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) (p = 0.004).

Conclusion: Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
Vaccination status of the patients (n = 921).
Figure 2
Figure 2
Prevalence of the SARS-COV-2 variants (n = 342). SARS-COV-2, severe acute respiratory infection-coronavirus-2
Figure 3
Figure 3
Mortality rates according to age groups in unvaccinated and vaccinated patients.
See this image and copyright information in PMC

References

    1. Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020;323:2052–2059. - PMC - PubMed
    1. Grasselli G, Zangrillo A, Zanella A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323:1574–1581. - PMC - PubMed
    1. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–1062. - PMC - PubMed
    1. Dallmeier K, Meyfroidt G, Neyts J. COVID-19 and the intensive care unit: vaccines to the rescue. Intensive Care Med. 2021;47:786–789. - PMC - PubMed
    1. Odabasi Z, Cinel I. Consideration of Severe Coronavirus Disease 2019 As Viral Sepsis and Potential Use of Immune Checkpoint Inhibitors. Crit Care Explor. 2020;2:e0141. - PMC - PubMed

Publication types