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Review
. 2022 Dec;61(4):681-691.
doi: 10.20471/acc.2022.61.04.15.

PERINATAL ASPECTS OF SARS-CoV-2 INFECTION DURING PREGNANCY: A POTENTIAL CAUSE FOR CONCERN

Ana Meyra Potkonjak  1 , Vesna Gall  1 , Danko Milošević  2   3 , Vesna Košec  1 , Boris Filipović-Grčić  2   3
Affiliations
Review

PERINATAL ASPECTS OF SARS-CoV-2 INFECTION DURING PREGNANCY: A POTENTIAL CAUSE FOR CONCERN

Ana Meyra Potkonjak et al. Acta Clin Croat. 2022 Dec.

Abstract

Ever since the beginning of COVID-19 pandemic, uncertainty regarding clinical presentation and differences among various subpopulations exist. With more than 209,870,000 confirmed cases and more than 4,400,000 deaths worldwide, we are facing the new era of health crisis which will undoubtedly impair global health, economic and social circumstances. In the past year, numerous genetic mutations which code SARS-CoV-2 proteins led to the occurrence of new viral strains, with higher transmission rates. Apart from the implementation of vaccination, the effect of SARS-CoV-2 on pregnancy outcome and maternal fetal transmission remains an important concern. Although neonates diagnosed with COVID-19 were mostly asymptomatic or presented with mild disease, the effect on early pregnancy is yet to be evident. While positive finding of SARS-CoV-2 RNA in some samples such as amniotic fluid, placental tissue, cord blood and breast milk exists, additional research should confirm its association with transplacental transmission.

Keywords: COVID-19; Neonates; Pregnancy; SARS-CoV-2; Vertical transmission.

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References

    1. who.int [Internet] Geneva: World Health Organization; c2020 [cited 2021 Jan 12]. Available from: http://covid19.who.int/
    1. cdc.gov [Internet] Washington: Centers for Disease Control and prevention; c2021 [cited 2021 Mar 21]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/variant-surveill...
    1. Breslin N, Baptiste C, Gyamfi-Bannerman C, Miller R, Martinez R, Bernstein K, et al. Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM. 2020;2:100118. [cited 2020 June 4] [Internet]10.1016/j.ajogmf.2020.100118 - DOI - PMC - PubMed
    1. Wong SF, Chow KM, Leung TN, Ng WF, Ng TK, Shek CC, et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol. 2004;191(1):292–7. 10.1016/j.ajog.2003.11.019 - DOI - PMC - PubMed
    1. Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415–26. [cited 2020 June 9] [Internet]10.1016/j.ajog.2020.02.017 - DOI - PMC - PubMed