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Meta-Analysis
. 2023 Aug 9:45:153.
doi: 10.11604/pamj.2023.45.153.40741. eCollection 2023.

Prevalence and distribution of primary glomerular diseases in Africa: a systematic review and meta-analysis of observational studies

Udeme Ekpenyong Ekrikpo  1 , Patience Ngozi Obiagwu  2 , Aniema Isaac Udo  1 , Ijezie Innocent Chukwuonye  3 , Jean Jacques Noubiap  4 , Ugochi Sophia Okpechi-Samuel  5 , Udeme-Abasi Nelson Udoudo  1 , Elliot Koranteng Tannor  6   7 , Stanley Chidozie Ngoka  8 , Ikechukwu Okeke Mbah  9 , Aminu Kasarawa Bello  10 , Ikechi Gareth Okpechi  10
Affiliations
Meta-Analysis

Prevalence and distribution of primary glomerular diseases in Africa: a systematic review and meta-analysis of observational studies

Udeme Ekpenyong Ekrikpo et al. Pan Afr Med J. .

Abstract

Glomerulonephritis (GN) is a predominant cause of kidney failure in Africa. The prevalence of primary GNs varies widely across Africa depending on the relative proportion of secondary GNs and genetic predispositions. We assessed the overall and sub-regional prevalence of primary GN and its histologic subtypes in Africa. We searched PubMed, EMBASE and African Journals Online for studies of biopsy-proven primary GNs across all age groups in Africa published between 2010 and 2022. Data for primary GNs [minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), mesangioproliferative GN (MesPGN), membranoproliferative GN (MPGN), post-infectious GN (PIGN), IgA Nephropathy (IgAN), and crescentic GN (CresGN)] were extracted. Pooled prevalence was determined using the random effects model. Seventeen eligible articles (n = 6,494 individuals) from 8 African countries met the inclusion criteria. The overall pooled prevalence of FSGS, MCD, MN, MPGN, MesPGN, PIGN, IgAN and CresGN was 26.10%, 22.40%, 8.40%, 6.40%, 6.40%, 2.60%, 2.60%, 1.40%, respectively. Only 4 studies (23.5%) used light microscopy (LM), immunofluorescence (IF), and electron microscopy (EM) for diagnosis. There were significant differences in the distribution of histologic subtypes in the paediatric compared to the adult population and across geographic sub-regions, with West Africa having a higher prevalence of FSGS. Overall, the dominance of FSGS across most regions and age groups has implications for disease diagnosis and ongoing care. Research efforts to understand the impact of this trend on kidney disease outcomes and efforts to improve kidney biopsy practice as a means of early disease detection are needed in Africa.

Keywords: Africa; Glomerulonephritis; IgA nephropathy; focal segmental glomerulosclerosis; kidney biopsy; minimal change disease.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
PRISMA flow chart of study selection
Figure 2
Figure 2
pooled prevalence of primary glomerular diseases in adult and paediatric populations in Africa
Figure 3
Figure 3
prevalence of primary glomerular disease sun-types across African sub-regions; FSGS-focal segmental glomerulosclerosis; MCD-minimal change disease; MN-membranous nephropathy; MPGN-membranoproliferative glomerulonephritis; MesPGN-mesangioproliferative glomerulo nephritis; IgAN - IgA nephropathy; PIGN - post-infectious glomerulonephritis; CresGN - crescentic glomerulonephritis
See this image and copyright information in PMC

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