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. 2023 Oct 3;10(10):ofad496.
doi: 10.1093/ofid/ofad496. eCollection 2023 Oct.

Genomic Analysis of Group B Streptococcus Carriage Isolates From Botswana Reveals Distinct Local Epidemiology and Identifies Novel Strains

Karen L Hanze Villavicencio  1   2 , Megan J Job  3 , Anne Claire Burghard  3   4 , Allison Taffet  3 , Francis M Banda  5 , Moses Vurayai  6 , Margaret Mokomane  6 , Tonya Arscott-Mills  5   7   8 , Tiny Mazhani  5 , Seeletso Nchingane  9 , Brady Thomas  10 , Andrew P Steenhoff  1   2   5   7   8 , Adam J Ratner  3   11
Affiliations

Genomic Analysis of Group B Streptococcus Carriage Isolates From Botswana Reveals Distinct Local Epidemiology and Identifies Novel Strains

Karen L Hanze Villavicencio et al. Open Forum Infect Dis. .

Abstract

In pregnant people colonized with group B Streptococcus (GBS) in Botswana, we report the presence/expansion of sequence types 223 and 109, a low rate of erythromycin resistance, and 3 novel sequence types. These data highlight the importance of local epidemiologic studies of GBS, a significant source of neonatal disease.

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Conflict of interest statement

Potential conflicts of interest. All authors: No reported conflicts.

Figures

Figure 1.
Figure 1.
A, Serotype, sequence type (ST), and clonal complex (CC) of group B Streptococcus (GBS) isolates from pregnant people in Botswana. B, GBS whole-genome similarity was assessed using Mashtree 1.2.0 and visualized using the Microreact web server. Nodes are shaded by CC. Branch lengths and scale bar represent Mash distances. Specific ST groupings discussed in the text (ST109 and ST223) are indicated.
See this image and copyright information in PMC

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