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. 2024 Feb;35(2):130-135.
doi: 10.1177/09564624231206845. Epub 2023 Oct 23.

Use of ceftriaxone as an alternative treatment method in pregnant women diagnosed with syphilis - a single centre experience

Ilona Hartmane  1   2 , Iveta Ivdra  1   2 , Ingmars Mikazans  1   2 , Aleksejs Princevs  1 , Irena Teterina  3 , Vanda Bondare-Ansberga  1   2 , Lelde Reinberga  1   2
Affiliations

Use of ceftriaxone as an alternative treatment method in pregnant women diagnosed with syphilis - a single centre experience

Ilona Hartmane et al. Int J STD AIDS. 2024 Feb.

Abstract

Background: There are few data on the use of ceftriaxone in pregnant women diagnosed with syphilis. The aim of this study was to investigate the safety and efficacy of ceftriaxone as an alternative treatment option for syphilis during pregnancy.

Methods: A retrospective analysis of 79 pregnant women diagnosed with syphilis and treated with ceftriaxone was conducted.

Results: No cases of intolerance, Jarisch-Herxheimer reactions, or allergic reactions were recorded. The average time to seronegativation for secondary syphilis with symptoms was 6.14 months ± 2.76, and for latent forms, it was 7.52 months ± 1.84. Patients received no additional treatment. No serious adverse drug reactions were reported.

Conclusions: Data from our study support the use of ceftriaxone as an effective and safe alternative treatment for pregnant women diagnosed with syphilis when penicillin therapy is contraindicated or unavailable.

Keywords: Syphilis; antibiotic; pregnancy; treatment.

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Conflict of interest statement

Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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