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Randomized Controlled Trial
. 2023 Dec:291:128-130.
doi: 10.1016/j.ejogrb.2023.10.004. Epub 2023 Oct 6.

Asymptomatic CMV infection at birth following maternal primary infection despite valacyclovir treatment and a subsequent negative amniocentesis. Case report

Maria Stefania Toti  1 , Lorenzo Zammarchi  2 , Lucia Pasquini  3 , Irene Campolmi  4 , Giulia Modi  5 , Beatrice Borchi  6 , Alessandro Bartoloni  7 , Michele Trotta  8 , Luisa Galli  9 , Roberto Bernardini  10
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Free article
Randomized Controlled Trial

Asymptomatic CMV infection at birth following maternal primary infection despite valacyclovir treatment and a subsequent negative amniocentesis. Case report

Maria Stefania Toti et al. Eur J Obstet Gynecol Reprod Biol. 2023 Dec.
Free article

Abstract

Valacyclovir is currently the only pharmacological intervention demonstrated to reduce the risk of vertical CMV congenital infection within a randomized clinical trial in case of primary infection during pregnancy. So far, no data are available on the prognosis of children with congenital CMV infection diagnosed at birth after a negative amniocentesis whose mother were treated with valacyclovir during pregnancy, therefore it is essential to carry out a rigorous neurocognitive follow-up in these children in order to investigate the potential clinical consequence.

Keywords: Antiviral therapy; Cytomegalovirus; Maternal primary infection; Valacyclovir; Vertical transmission.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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