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Case Reports
. 2023 Dec;27(6):377-378.
doi: 10.1016/j.jaapos.2023.08.012. Epub 2023 Oct 21.

Paradoxical inflammatory blepharitis in a patient with Crohn's disease

Inès Chircop  1 , Damien Guindolet  2 , Maxime Battistella  3 , Christine Martinez-Vinson  4 , Emmanuelle Bourrat  5
Affiliations
Case Reports

Paradoxical inflammatory blepharitis in a patient with Crohn's disease

Inès Chircop et al. J AAPOS. 2023 Dec.

Abstract

We report the case of a 15-year-old boy with severe inflammatory blepharitis who was being treated with a TNFα inhibitor for Crohn's disease (CD). This case shows the potential utility of a skin biopsy in distinguishing metastatic CD associated with granulomatous blepharitis from a paradoxical blepharitis induced by anti-TNFα. It also demonstrates that ustekinumab can be considered in patients with CD who cannot tolerate TNFα inhibitors because of cutaneous paradoxical reactions.

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