Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan;48(1):74-81.
doi: 10.1002/jpen.2570. Epub 2023 Nov 19.

Factors associated with enteral autonomy after reanastomosis in infants with intestinal failure and ostomy: A descriptive cohort study

Arjun D Patel  1 , Gina Casini  2 , Joseph L Hagan  2 , Anne Debuyserie  2 , Adam M Vogel  3 , Laura Gollins  4 , Amy B Hair  2 , Caraciolo J Fernandes  2 , Muralidhar H Premkumar  2
Affiliations

Factors associated with enteral autonomy after reanastomosis in infants with intestinal failure and ostomy: A descriptive cohort study

Arjun D Patel et al. JPEN J Parenter Enteral Nutr. 2024 Jan.

Abstract

Background: To determine variables associated with outcomes in infants with intestinal failure (IF) and ostomy following reanastomosis (RA).

Methods: A single-center, descriptive cohort study of 120 infants with IF and a stoma from January 2011 to December 2020 with subsequent RA during initial hospitalization. The primary outcome was achievement of enteral autonomy (EA) following RA. Other outcomes were duration of hospital stay, and mortality. Penalized logistic regression and linear regression were used for data analysis.

Results: The median gestational age was 26 weeks, and the median birth weight was 890 g. Three infants died. The median duration between ostomy creation and RA was 80 days (interquartile range; 62.5, 100.5). For each additional day of discontinuity, the odds of EA decreased by 2% (odds ratio [OR] = 0.980; 95% confidence interval [CI]: 0.962, 0.999; P = 0.038), and death increased by 4.2% (OR = 1.042; 95% CI: 1.010, 1.075; P = 0.009). For each additional mL/kg/day of enteral feeds at RA, the odds of EA increased by 7.5% (OR = 1.075; 95% CI: 1.027, 1.126, P = 0.002) and duration of hospital stay decreased by 0.35 days (slope coefficient = -0.351; 95% CI: -0.540, -0.163; P < 0.001).

Conclusion: Shorter duration of intestinal discontinuity and enteral nutrition before RA could positively influence EA and duration of stay in infants with IF and ostomy following RA.

Keywords: colostomy; ileostomy; intestinal failure; jejunostomy; ostomy; short bowel syndrome.

PubMed Disclaimer

References

REFERENCES

    1. Goulet O, Ruemmele F, Lacaille F, Colomb V. Irreversible intestinal failure. J Pediatr Gastroenterol Nutr. 2004;38:250-269.
    1. Modi BP, Galloway DP, Gura K, et al. ASPEN definitions in pediatric intestinal failure. JPEN Parenter Enteral Nutr. 2022;46:42-59.
    1. Gattini D, Roberts AJ, Wales PW, et al. Trends in pediatric intestinal failure: a multicenter, multinational study. J Pediatr. 2021;237:16-23.
    1. Squires RH, Duggan C, Teitelbaum DH, et al. Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium. J Pediatr. 2012;161:723-728.
    1. Grant D, Abu-Elmagd K, Mazariegos G, et al. Intestinal transplant registry report: global activity and trends. Am J Transplant (AJT). 2015;15:210-219.

LinkOut - more resources