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Review
. 2023 Sep 25;185(39):V04230258.

The clinical use of polygenic risk scores

[Article in Danish]
Thorkild Terkelsen  1 , Thomas Folkmann Hansen  2 , Morten Krogh Herlin  1 , Malene Djursby  3 , Mette Nyegaard  4 , Inge Søkilde Pedersen  5 , Dorte Launholt Lildballe  6 , Søren Lejsted Færgeman  1 , Lone Sunde  7 , Mads Engel Hauberg  8
Affiliations
  • PMID: 37873989
Free article
Review

The clinical use of polygenic risk scores

[Article in Danish]
Thorkild Terkelsen et al. Ugeskr Laeger. .
Free article

Abstract

Polygenic risk scores (PRS) identify at-risk individuals for many common diseases. A discussion of strengths and limitations is carried out in this review. PRS complement traditional genetic testing and have shown utility in establishing a proper diagnosis and guiding primary and secondary prevention. Some individuals with high PRS have risks similar to those with monogenic predisposition. Limitations include potential misinterpretations, problems with application across ancestries, and limited usefulness in low-heritability traits. Despite its shortcomings PRS are predicted to play major roles in the future of personal medicine and genetic testing.

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