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. 2024 Feb 5;137(3):294-302.
doi: 10.1097/CM9.0000000000002841. Epub 2023 Oct 24.

Global and regional trends in the incidence and mortality burden of endometrial cancer, 1990-2019: Updated results from the Global Burden of Disease Study, 2019

Jianyang Feng  1 , Rongjin Lin  1 , Haoxian Li  1 , Jiayan Wang  2 , Hong He  1
Affiliations

Global and regional trends in the incidence and mortality burden of endometrial cancer, 1990-2019: Updated results from the Global Burden of Disease Study, 2019

Jianyang Feng et al. Chin Med J (Engl). .

Abstract

Background: The disease burdens for endometrial cancer (EC) vary across different countries and geographical regions and change every year. Herein, we reported the updated results of the Global Burden of Disease Study 2019 on EC with respect to age-standardized incidence and mortality from 1990 to 2019.

Methods: The annual percentage change (APC) of incidence and mortality was evaluated using joinpoint regression analysis to examine the temporal trends during the same timeframe in terms of the global landscape, different sociodemographic indices (SDI), and geographic regions. The relationship between Human Development Index (HDI) and incidence and mortality was additionally explored.

Results: The age-standardized incidence rates (ASIRs) revealed a significant average global elevation by 0.5% per year (95% confidence interval [CI], 0.3-0.7; P <0.001). The age-standardized mortality rates (ASMRs), in contrast, fell by an average of 0.8% per year (95% CI, -1.0 to -0.7; P <0.001) worldwide. The ASIRs and ASMRs for EC varied across different SDIs and geographical regions. We noted four temporal trends and a significant reduction by 0.5% per year since 2010 in the ASIR, whereas we detected six consecutively decreasing temporal trends in ASMR during the entire period. Notably, the estimated APCs were significantly positively correlated with HDIs (ρ = 0.22; 95% CI, 0.07-0.35; P = 0.003) with regard to incident cases in 2019.

Conclusions: Incidence rates for EC reflected a significant increase overall (although we observed a decline since 2010), and the death rates declined consecutively from 1990 to 2019. We posit that more precise strategies can be tailored and then implemented based on the distinct age-standardized incidence and mortality burden in different geographical areas.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
The association between (A) ASIRs and SDI, (B) ASMRs and SDIs of different geographical regions. ASIR: Age-standardized incidence rate; ASMR: Age-standardized mortality rate; SDI: Sociodemographic index.
Figure 2
Figure 2
The age-standardized incidence (A) and temporal mortality trends (B) for EC worldwide, 1990–2019. *P <0.05. APC: Annual percentage change; EC: Endometrial cancer.
Figure 3
Figure 3
The association between EAPCs and HDI in ASIR and ASMR in 2019, respectively. The size of the circle correlates with the cases of EC. The ρ indices and P-values presented in (A) and (B) were derived from Pearson's correlation analysis. ASIR: Age-standardized incidence rate; ASMR: Age-standardized mortality rate; CI: Confidence interval; EAPC: Estimated annual percentage change; EC: Endometrial cancer; HDI: Human Development Index.
See this image and copyright information in PMC

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