Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Dec 12;13(12):OF8.
doi: 10.1158/2159-8290.CD-ND2023-0011.

Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC

No authors listed
Comment

Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC

No authors listed. Cancer Discov. .

Abstract

In separate trials, the RET inhibitor selpercatinib showed superiority over standard of care in RET-mutated medullary thyroid cancer and in RET fusion-positive non-small cell lung cancer-although researchers say more follow-up is needed. The findings highlight the importance of tumor sequencing.

PubMed Disclaimer

Comment on

  • First-Line Selpercatinib or Chemotherapy and Pembrolizumab in RET Fusion-Positive NSCLC.
    Zhou C, Solomon B, Loong HH, Park K, Pérol M, Arriola E, Novello S, Han B, Zhou J, Ardizzoni A, Mak MP, Santini FC, Elamin YY, Drilon A, Wolf J, Payakachat N, Uh MK, Rajakumar D, Han H, Puri T, Soldatenkova V, Lin AB, Lin BK, Goto K; LIBRETTO-431 Trial Investigators. Zhou C, et al. N Engl J Med. 2023 Nov 16;389(20):1839-1850. doi: 10.1056/NEJMoa2309457. Epub 2023 Oct 21. N Engl J Med. 2023. PMID: 37870973 Free PMC article. Clinical Trial.

MeSH terms

LinkOut - more resources