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Editorial
. 2023 Oct 24;119(13):2259-2261.
doi: 10.1093/cvr/cvad139.

Updating the paradigm: inflammation as a targetable modulator of medial vascular calcification

Mandy E Turner  1 , Elena Aikawa  1   2
Affiliations
Editorial

Updating the paradigm: inflammation as a targetable modulator of medial vascular calcification

Mandy E Turner et al. Cardiovasc Res. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Distinguishing features of the inflammatory profile in intimal and medial vascular calcification. Intimal vascular calcification, concomitant with atherosclerosis, is hallmarked by risk factors such as hyperlipidemia, hypertension, and diabetes. Local immune cell infiltration and pro-inflammatory lipid deposition in the tunica intima precipitates calcification. Medial calcification is hallmarked by chronic kidney disease, advancing age, and diabetes as well, however it is not typically coupled strongly with local inflammation. This article updates the current paradigm by showing that attenuating local smooth muscle cell inflammatory pathways (NLRP3 and IL1-β) through SGLT2 inhibitor canaglifozin can reduce calcification in the tunica media.
See this image and copyright information in PMC

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References

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