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. 2023 Oct 23;33(20):R1044-R1046.
doi: 10.1016/j.cub.2023.08.045.

Extensive gene loss parallels kidney aglomerulism in Syngnathidae

Bernardo Pinto  1 , André M Machado  1 , J Miguel Cordeiro  2 , Salman Malakpour Kolbadinezhad  3 , Elza Fonseca  2 , José Pedro Andrade  4 , Jorge Palma  4 , Raquel Ruivo  2 , Nuno Monteiro  5 , Jonathan M Wilson  6 , L Filipe C Castro  7
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Free article

Extensive gene loss parallels kidney aglomerulism in Syngnathidae

Bernardo Pinto et al. Curr Biol. .
Free article

Abstract

The eccentric seahorses, seadragons, pipehorses and pipefishes (Syngnathidae) have an aglomerular kidney1. Here, we show that nephron genes2 conserved in Bilateria are secondarily eroded/deleted in Syngnathidae genomes. A transcriptome enrichment analysis suggests the predominance of excretion processes in the Syngnathidae kidney. In a lineage where crypsis and idleness are tightly associated, we propose that aglomerulism evolved as an energy-saving strategy.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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