'Zombie' proviruses in the spotlight: exploring the dark side of HIV persistence

Affiliations

¹ Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
² Department of Health Informatics, Niigata University of Health and Welfare, Niigata, Japan.

Comment

Alexander O Pasternak et al. AIDS. 2023.

. 2023 Nov 15;37(14):2239-2241.

doi: 10.1097/QAD.0000000000003721. Epub 2023 Oct 26.

¹ Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
² Department of Health Informatics, Niigata University of Health and Welfare, Niigata, Japan.

No abstract available

Comment on

Long-term persistence of transcriptionally active 'defective' HIV-1 proviruses: implications for persistent immune activation during antiretroviral therapy.
Singh K, Natarajan V, Dewar R, Rupert A, Badralmaa Y, Zhai T, Winchester N, Scrimieri F, Smith M, Davis I, Lallemand P, Giglietti A, Hensien J, Buerkert T, Goshu B, Rehm CA, Hu Z, Lane HC, Imamichi H. Singh K, et al. AIDS. 2023 Nov 15;37(14):2119-2130. doi: 10.1097/QAD.0000000000003667. Epub 2023 Aug 22. AIDS. 2023. PMID: 37555786 Free PMC article.

1. Eisele E, Siliciano RF. Redefining the viral reservoirs that prevent HIV-1 eradication . Immunity 2012; 37:377–388.
1. Deeks SG, Archin N, Cannon P, Collins S, Jones RB, de Jong MAWP, et al. Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021 . Nat Med 2021; 27:2085–2098.
1. Pasternak AO, Berkhout B. HIV persistence: silence or resistance? . Curr Opin Virol 2023; 59:101301.
1. Bruner KM, Murray AJ, Pollack RA, Soliman MG, Laskey SB, Capoferri AA, et al. Defective proviruses rapidly accumulate during acute HIV-1 infection . Nat Med 2016; 22:1043–1049.
1. Hiener B, Horsburgh BA, Eden JS, Barton K, Schlub TE, Lee E, et al. Identification of genetically intact HIV-1 proviruses in specific CD4(+) T cells from effectively treated participants . Cell Rep 2017; 21:813–822.