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Observational Study
. 2024 Jul;30(5):2965-2984.
doi: 10.1111/odi.14778. Epub 2023 Oct 25.

Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study

Gerardo Gilligan  1 , René Panico  1 , Jerónimo Lazos  1 , Rosana Morelatto  2 , Paola Belardinelli  2 , Maria Ines Criscuolo  2 , Nicolas Bolesina  2 , Ignacio Molina Ávila  3 , Juan Martin Pimentel Solá  3 , Emilce Rivarola  4 , Maria Jimena Morgante  4 , Maria Eugenia Ingrassia Tonelli  5 , Javier Gimenez  6 , Pablo Doratti  6 , Laura Cecilia Werner  7 , Ana Carolina Prado-Ribeiro  8   9 , Thais Bianca Brandão  8 , Aljomar Jose Vechiato-Filho  8   9 , Maria Claudia Cuzzullin  9 , Cristina Saldivia-Siracusa  9 , Marcio Ajudarte Lopes  9 , Michelle Agostini  10 , Mario José Romañach  10 , Aline Corrêa Abrahão  10 , Thamyres Campos Fonsêca  10 , Estela Kaminagakura  11 , Ana Lia Anbinder  11 , Kamilla Santos Alves  11 , Maria Leticia de Almeida Lança  11 , Sonia Sacsaquispe-Contreras  12 , Karem Rodriguez Ibazetta  12 , Roberto Gerber-Mora  13 , Saray Aranda Romo  14 , Francisco Javier Tejeda Nava  14 , Karina Cordero-Torres  15 , Ricardo Moreno Silva  15 , Wilfredo Gonzalez-Arriagada  16 , Raiza Toro  17 , Felipe Martins Silveira  18 , Natalia Gonzalez  18 , Pablo Agustin Vargas  9 , Alan Roger Santos-Silva  9 , Ronell Bologna-Molina  18 , Mariana Villarroel-Dorrego  17 , Benjamin Martinez  19 , Eduardo Piemonte  1
Affiliations
Observational Study

Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study

Gerardo Gilligan et al. Oral Dis. 2024 Jul.

Abstract

Objective: To determine the frequency of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD), and the epidemiological profile and traditional risk factors in Latin America.

Methods: A retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential-OSCC versus OSCC-de novo (OSCC-dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's t-test, and qualitative variables with chi-square.

Results: In total, 2705 OSCC were included with a mean age of 62.8 years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC-dn, while s-OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD.

Conclusions: In Latin America, OSCC-dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.

Keywords: Latin America; leukoplakia; oral cancer; oral potentially malignant disorders; oral squamous cell carcinoma.

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References

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