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Genetic Characterization of Extensively Drug-Resistant Shigella sonnei Infections, Spain, 2021-2022

Camille Jacqueline et al. Emerg Infect Dis. 2023 Nov.

Abstract

In 2022, the United Kingdom reported an increase in drug resistance in Shigella sonnei isolates. We report 33 cases in Spain genetically related to the UK cases and 4 cases with similar antimicrobial resistance profiles infected with genetically distant strains. Our results suggest circulation of multiple genetic clusters of multidrug-resistant S. sonnei in Spain.

Keywords: Shigella sonnei; Spain; XDR; antimicrobial resistance; bacteria; drug resistance; extensively drug-resistant; infections; sexual transmission.

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Figures

Figure
Figure
Phylogenetic analysis of ST152 isolates showing 2 clusters from an investigation of suspected multidrug-resistant Shigella sonnei in Spain. Red text indicates reference sequences from the United Kingdom; blue text indicates assembly barcodes of ST152 feeding sequences available on Enterobase (https://enterobase.warwick.ac.uk) from 2019 to 2022. Green arrowheads indicate cases associated with MSM; green brackets connect known sexual partners. Orange arrowheads indicate cases in heterosexual persons (female or male); gray arrowheads indicate sexual behavior was unknown. A sequence from another sequence type was used as an outgroup. Numbers on branches indicate bootstrap values >80%. MSM, men who have sex with men; ST, sequence type.
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