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. 2023 Nov;29(11):2395-2397.
doi: 10.3201/eid2911.230499.

Case of Carbapenem-Resistant Salmonella Typhi Infection, Pakistan, 2022

Summiya Nizamuddin, Ejaz Ahmed Khan, Marie Anne Chattaway, Gauri Godbole

Case of Carbapenem-Resistant Salmonella Typhi Infection, Pakistan, 2022

Summiya Nizamuddin et al. Emerg Infect Dis. 2023 Nov.

Abstract

Salmonella Typhi infection in a patient in Pakistan initially responded to standard treatment but failed to respond to subsequent treatment. The first strain was susceptible to carbapenems and azithromycin; subsequent strains harbored the NDM-5 gene. Treatment with a combination of intravenous meropenem and colistin was successful. Carbapenem-resistant Salmonella Typhi emergence will hinder treatment.

Keywords: Pakistan; Salmonella Typhi; Salmonella enteria serovar Typhi; antimicrobial resistance; bacteria; carbapenem resistance; diagnosis; therapy; typhoid fever.

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Figures

Figure
Figure
Salmonella Typhi colony on MacConkey agar, isolated from patient during clinical relapse of carbapenem-resistant Salmonella Typhi infection, Pakistan, 2022. Variant 1, circled in yellow, is a large gray dull colony. Variant 2, circled in black, is a small whitish shiny colony.
See this image and copyright information in PMC

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